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The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Lou M, Garrett TP, McKern NM, Hoyne PA, Epa VC, Bentley JD, Lovrecz GO, Cosgrove LJ, Frenkel MJ, Ward CW. Lou M, et al. Among authors: epa vc. Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12429-34. doi: 10.1073/pnas.0605395103. Epub 2006 Aug 7. Proc Natl Acad Sci U S A. 2006. PMID: 16894147 Free PMC article.
Structure of the insulin receptor ectodomain reveals a folded-over conformation.
McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW. McKern NM, et al. Among authors: epa vc. Nature. 2006 Sep 14;443(7108):218-21. doi: 10.1038/nature05106. Epub 2006 Sep 6. Nature. 2006. PMID: 16957736
The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design.
Carmichael JA, Lawrence MC, Graham LD, Pilling PA, Epa VC, Noyce L, Lovrecz G, Winkler DA, Pawlak-Skrzecz A, Eaton RE, Hannan GN, Hill RJ. Carmichael JA, et al. Among authors: epa vc. J Biol Chem. 2005 Jun 10;280(23):22258-69. doi: 10.1074/jbc.M500661200. Epub 2005 Apr 4. J Biol Chem. 2005. PMID: 15809296 Free article.
31 results