Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC.
Siu KL, Yuen KS, Castaño-Rodriguez C, Ye ZW, Yeung ML, Fung SY, Yuan S, Chan CP, Yuen KY, Enjuanes L, Jin DY.
Siu KL, et al. Among authors: enjuanes l.
FASEB J. 2019 Aug;33(8):8865-8877. doi: 10.1096/fj.201802418R. Epub 2019 Apr 29.
FASEB J. 2019.
PMID: 31034780
Free PMC article.
Taken together, our findings reveal a new mechanism by which SARS-CoV ORF3a protein activates NF-kappaB and the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of p105 and ASC.-Siu, K.-L., Yuen, K.-S., Castano-Rodriguez, C., Ye, Z.-W., Yeung, M.-L., F …
Taken together, our findings reveal a new mechanism by which SARS-CoV ORF3a protein activates NF-kappaB and the NLRP3 inflammasome by promot …