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A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockade.
Geuijen C, Tacken P, Wang LC, Klooster R, van Loo PF, Zhou J, Mondal A, Liu YB, Kramer A, Condamine T, Volgina A, Hendriks LJA, van der Maaden H, Rovers E, Engels S, Fransen F, den Blanken-Smit R, Zondag-van der Zande V, Basmeleh A, Bartelink W, Kulkarni A, Marissen W, Huang CY, Hall L, Harvey S, Kim S, Martinez M, O'Brien S, Moon E, Albelda S, Kanellopoulou C, Stewart S, Nastri H, Bakker ABH, Scherle P, Logtenberg T, Hollis G, de Kruif J, Huber R, Mayes PA, Throsby M. Geuijen C, et al. Among authors: engels s. Nat Commun. 2021 Jul 21;12(1):4445. doi: 10.1038/s41467-021-24767-5. Nat Commun. 2021. PMID: 34290245 Free PMC article.
Outer membrane vesicles engineered to express membrane-bound antigen program dendritic cells for cross-presentation to CD8+ T cells.
Schetters STT, Jong WSP, Horrevorts SK, Kruijssen LJW, Engels S, Stolk D, Daleke-Schermerhorn MH, Garcia-Vallejo J, Houben D, Unger WWJ, den Haan JMM, Luirink J, van Kooyk Y. Schetters STT, et al. Among authors: engels s. Acta Biomater. 2019 Jun;91:248-257. doi: 10.1016/j.actbio.2019.04.033. Epub 2019 Apr 17. Acta Biomater. 2019. PMID: 31003032 Free article.
Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression.
Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y. Unger WW, et al. Among authors: engels s. Oncoimmunology. 2014 Oct 31;4(8):e970462. doi: 10.4161/21624011.2014.970462. eCollection 2015 Aug. Oncoimmunology. 2014. PMID: 26405564 Free PMC article.
Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells.
Perdicchio M, Ilarregui JM, Verstege MI, Cornelissen LA, Schetters ST, Engels S, Ambrosini M, Kalay H, Veninga H, den Haan JM, van Berkel LA, Samsom JN, Crocker PR, Sparwasser T, Berod L, Garcia-Vallejo JJ, van Kooyk Y, Unger WW. Perdicchio M, et al. Among authors: engels s. Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3329-34. doi: 10.1073/pnas.1507706113. Epub 2016 Mar 3. Proc Natl Acad Sci U S A. 2016. PMID: 26941238 Free PMC article.
Bacterial inclusion bodies function as vehicles for dendritic cell-mediated T cell responses.
Schetters STT, Jong WSP, Kruijssen LJW, van den Berg van Saparoea HB, Engels S, Unger WWJ, Houben D, den Haan JMM, Luirink J, Kooyk YV. Schetters STT, et al. Among authors: engels s. Cell Mol Immunol. 2020 Apr;17(4):415-417. doi: 10.1038/s41423-019-0298-x. Epub 2019 Oct 8. Cell Mol Immunol. 2020. PMID: 31595053 Free PMC article. No abstract available.
The neo-open reading frame peptides that comprise the tumor framome are a rich source of neoantigens for cancer immunotherapy.
Martin MV, Aguilar-Rosas S, Franke K, Pieterse M, van Langelaar J, Schreurs RR, Bijlsma MF, Besselink MG, Koster J, Timens W, Khasraw M, Ashley DM, Keir ST, Ottensmeier CH, King EV, Verheij J, Waasdorp C, Valk PJM, Engels SA, Oostenbach E, van Dinter JT, Hofman DA, Mok JY, van Esch WJE, Wilmink H, Monkhorst K, Verheul HMW, Poel D, Hiltermann TJN, van Kempen LC, Groen HJ, Aerts JGJV, van Heesch S, Lowenberg B, Plasterk R, Kloosterman WP. Martin MV, et al. Among authors: engels sa. Cancer Immunol Res. 2024 Apr 4. doi: 10.1158/2326-6066.CIR-23-0158. Online ahead of print. Cancer Immunol Res. 2024. PMID: 38573707
107 results