Eng H - Search Results

1

An oral SARS-CoV-2 M^pro inhibitor clinical candidate for the treatment of COVID-19.

Owen DR, Allerton CMN, Anderson AS, Aschenbrenner L, Avery M, Berritt S, Boras B, Cardin RD, Carlo A, Coffman KJ, Dantonio A, Di L, Eng H, Ferre R, Gajiwala KS, Gibson SA, Greasley SE, Hurst BL, Kadar EP, Kalgutkar AS, Lee JC, Lee J, Liu W, Mason SW, Noell S, Novak JJ, Obach RS, Ogilvie K, Patel NC, Pettersson M, Rai DK, Reese MR, Sammons MF, Sathish JG, Singh RSP, Steppan CM, Stewart AE, Tuttle JB, Updyke L, Verhoest PR, Wei L, Yang Q, Zhu Y. Owen DR, et al. Among authors: eng h. Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2. Science. 2021. PMID: 34726479 Free article.

2

Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.

Eng H, Niosi M, McDonald TS, Wolford A, Chen Y, Simila ST, Bauman JN, Warmus J, Kalgutkar AS. Eng H, et al. Xenobiotica. 2010 Jun;40(6):369-80. doi: 10.3109/00498251003706598. Xenobiotica. 2010. PMID: 20297923

3

Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.

Sharma R, Eng H, Walker GS, Barreiro G, Stepan AF, McClure KF, Wolford A, Bonin PD, Cornelius P, Kalgutkar AS. Sharma R, et al. Among authors: eng h. Chem Res Toxicol. 2011 Dec 19;24(12):2207-16. doi: 10.1021/tx200329k. Epub 2011 Oct 4. Chem Res Toxicol. 2011. PMID: 21939274

4

Immune-mediated agranulocytosis caused by the cocaine adulterant levamisole: a case for reactive metabolite(s) involvement.

Wolford A, McDonald TS, Eng H, Hansel S, Chen Y, Bauman J, Sharma R, Kalgutkar AS. Wolford A, et al. Among authors: eng h. Drug Metab Dispos. 2012 Jun;40(6):1067-75. doi: 10.1124/dmd.112.045021. Epub 2012 Mar 5. Drug Metab Dispos. 2012. PMID: 22393119 Review.

5

Statistical methods for analysis of time-dependent inhibition of cytochrome p450 enzymes.

Yates P, Eng H, Di L, Obach RS. Yates P, et al. Among authors: eng h. Drug Metab Dispos. 2012 Dec;40(12):2289-96. doi: 10.1124/dmd.112.047233. Epub 2012 Aug 31. Drug Metab Dispos. 2012. PMID: 22942318

6

Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor.

Kalgutkar AS, Ryder TF, Walker GS, Orr ST, Cabral S, Goosen TC, Lapham K, Eng H. Kalgutkar AS, et al. Among authors: eng h. Drug Metab Dispos. 2013 Jul;41(7):1375-88. doi: 10.1124/dmd.113.051839. Epub 2013 Apr 22. Drug Metab Dispos. 2013. PMID: 23610086

7

Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.

Eng H, Sharma R, McDonald TS, Edmonds DJ, Fortin JP, Li X, Stevens BD, Griffith DA, Limberakis C, Nolte WM, Price DA, Jackson M, Kalgutkar AS. Eng H, et al. Drug Metab Dispos. 2013 Aug;41(8):1470-9. doi: 10.1124/dmd.113.052183. Epub 2013 May 7. Drug Metab Dispos. 2013. PMID: 23653442

8

In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes.

Sharma R, McDonald TS, Eng H, Limberakis C, Stevens BD, Patel S, Kalgutkar AS. Sharma R, et al. Among authors: eng h. Drug Metab Dispos. 2013 Dec;41(12):2148-57. doi: 10.1124/dmd.113.054254. Epub 2013 Sep 20. Drug Metab Dispos. 2013. PMID: 24056839

9

Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs.

Eng H, Sharma R, McDonald TS, Landis MS, Stevens BD, Kalgutkar AS. Eng H, et al. Xenobiotica. 2014 Sep;44(9):842-8. doi: 10.3109/00498254.2014.897011. Epub 2014 Mar 4. Xenobiotica. 2014. PMID: 24588343

10

Metabolites in safety testing assessment in early clinical development: a case study with a glucokinase activator.

Sharma R, Litchfield J, Atkinson K, Eng H, Amin NB, Denney WS, Pettersen JC, Goosen TC, Di L, Lee E, Pfefferkorn JA, Dalvie DK, Kalgutkar AS. Sharma R, et al. Among authors: eng h. Drug Metab Dispos. 2014 Nov;42(11):1926-39. doi: 10.1124/dmd.114.060087. Epub 2014 Aug 20. Drug Metab Dispos. 2014. PMID: 25142735

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