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Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.
Nat Commun. 2017.
PMID: 28839146
Free PMC article.
Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation.
Evans EL, Cuthbertson K, Endesh N, Rode B, Blythe NM, Hyman AJ, Hall SJ, Gaunt HJ, Ludlow MJ, Foster R, Beech DJ.
Evans EL, et al. Among authors: endesh n.
Br J Pharmacol. 2018 May;175(10):1744-1759. doi: 10.1111/bph.14188. Epub 2018 Apr 6.
Br J Pharmacol. 2018.
PMID: 29498036
Free PMC article.
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Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells.
Caolo V, Debant M, Endesh N, Futers TS, Lichtenstein L, Bartoli F, Parsonage G, Jones EA, Beech DJ.
Caolo V, et al. Among authors: endesh n.
Elife. 2020 Jun 2;9:e50684. doi: 10.7554/eLife.50684.
Elife. 2020.
PMID: 32484440
Free PMC article.
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Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat.
Viswambharan H, Yuldasheva NY, Imrie H, Bridge K, Haywood NJ, Skromna A, Hemmings KE, Clark ER, Gatenby VK, Cordell P, Simmons KJ, Makava N, Abudushalamu Y, Endesh N, Brown J, Walker AMN, Futers ST, Porter KE, Cubbon RM, Naseem K, Shah AM, Beech DJ, Wheatcroft SB, Kearney MT, Sukumar P.
Viswambharan H, et al. Among authors: endesh n.
Circ Res. 2021 Sep 17;129(7):720-734. doi: 10.1161/CIRCRESAHA.121.319517. Epub 2021 Aug 21.
Circ Res. 2021.
PMID: 34420367
Free PMC article.
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Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ.
Parsonage G, et al. Among authors: endesh n.
Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31.
Br J Pharmacol. 2023.
PMID: 36457143
Free PMC article.
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Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress.
Endesh N, Chuntharpursat-Bon E, Revill C, Yuldasheva NY, Futers TS, Parsonage G, Humphreys N, Adamson A, Morley LC, Cubbon RM, Prasad KR, Foster R, Lichtenstein L, Beech DJ.
Endesh N, et al.
Liver Int. 2023 Sep;43(9):2026-2038. doi: 10.1111/liv.15646. Epub 2023 Jun 22.
Liver Int. 2023.
PMID: 37349903
Free PMC article.
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