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Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, Cox AD, Der CJ. Blake DR, et al. Among authors: emanuele mj. Sci Signal. 2019 Jul 16;12(590):eaav7259. doi: 10.1126/scisignal.aav7259. Sci Signal. 2019. PMID: 31311847 Free PMC article.
Mass spectrometry-based selectivity profiling identifies a highly selective inhibitor of the kinase MELK that delays mitotic entry in cancer cells.
McDonald IM, Grant GD, East MP, Gilbert TSK, Wilkerson EM, Goldfarb D, Beri J, Herring LE, Vaziri C, Cook JG, Emanuele MJ, Graves LM. McDonald IM, et al. Among authors: emanuele mj. J Biol Chem. 2020 Feb 21;295(8):2359-2374. doi: 10.1074/jbc.RA119.011083. Epub 2020 Jan 2. J Biol Chem. 2020. PMID: 31896573 Free PMC article.
Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
Weng MT, Lee JH, Wei SC, Li Q, Shahamatdar S, Hsu D, Schetter AJ, Swatkoski S, Mannan P, Garfield S, Gucek M, Kim MK, Annunziata CM, Creighton CJ, Emanuele MJ, Harris CC, Sheu JC, Giaccone G, Luo J. Weng MT, et al. Among authors: emanuele mj. Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3659-67. doi: 10.1073/pnas.1207673110. Epub 2012 Dec 10. Proc Natl Acad Sci U S A. 2012. PMID: 23236152 Free PMC article.
Dissenting degradation: Deubiquitinases in cell cycle and cancer.
Bonacci T, Emanuele MJ. Bonacci T, et al. Among authors: emanuele mj. Semin Cancer Biol. 2020 Dec;67(Pt 2):145-158. doi: 10.1016/j.semcancer.2020.03.008. Epub 2020 Mar 20. Semin Cancer Biol. 2020. PMID: 32201366 Free PMC article. Review.
Elucidating Human Mitosis Using an Anaphase-Like Cell-Free System.
Wasserman D, Nachum S, Noach-Hirsh M, Auerbach N, Sheinberger-Chorni E, Enrico TP, Lahmi R, Emanuele MJ, Tzur A. Wasserman D, et al. Among authors: emanuele mj. Methods Mol Biol. 2021;2329:143-164. doi: 10.1007/978-1-0716-1538-6_11. Methods Mol Biol. 2021. PMID: 34085221 Free PMC article.
49 results