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ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
Hanson A, Elpek K, Duong E, Shallberg L, Fan M, Johnson C, Wallace M, Mabry GR, Sazinsky S, Pepper L, Shu CJ, Sathyanarayanan S, Zuerndorfer S, Simpson T, Gostissa M, Briskin M, Law D, Michaelson J, Harvey CJ. Hanson A, et al. Among authors: elpek k. PLoS One. 2020 Sep 24;15(9):e0239595. doi: 10.1371/journal.pone.0239595. eCollection 2020. PLoS One. 2020. PMID: 32970735 Free PMC article.
In vivo discovery of immunotherapy targets in the tumour microenvironment.
Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. Zhou P, et al. Among authors: elpek k. Nature. 2014 Feb 6;506(7486):52-7. doi: 10.1038/nature12988. Epub 2014 Jan 29. Nature. 2014. PMID: 24476824 Free PMC article.
ImmGen at 15.
Immunological Genome Project. Immunological Genome Project. Nat Immunol. 2020 Jul;21(7):700-703. doi: 10.1038/s41590-020-0687-4. Nat Immunol. 2020. PMID: 32577013 No abstract available.
Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2.
Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Acton SE, et al. Immunity. 2012 Aug 24;37(2):276-89. doi: 10.1016/j.immuni.2012.05.022. Epub 2012 Aug 9. Immunity. 2012. PMID: 22884313 Free PMC article.
38 results