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A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.
Raimondi S, Porcari R, Mangione PP, Verona G, Marcoux J, Giorgetti S, Taylor GW, Ellmerich S, Ballico M, Zanini S, Pardon E, Al-Shawi R, Simons JP, Corazza A, Fogolari F, Leri M, Stefani M, Bucciantini M, Gillmore JD, Hawkins PN, Valli M, Stoppini M, Robinson CV, Steyaert J, Esposito G, Bellotti V. Raimondi S, et al. Among authors: ellmerich s. Sci Rep. 2017 Apr 21;7:46711. doi: 10.1038/srep46711. Sci Rep. 2017. PMID: 28429761 Free PMC article.
Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.
Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ, Minogue S, Dhillon AP, Taylor GW, Bradwell AR, Petrie A, Gillmore JD, Bellotti V, Botto M, Hawkins PN, Pepys MB. Bodin K, et al. Among authors: ellmerich s. Nature. 2010 Nov 4;468(7320):93-7. doi: 10.1038/nature09494. Epub 2010 Oct 20. Nature. 2010. PMID: 20962779 Free PMC article.
Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use.
Pepys MB, Gallimore JR, Lloyd J, Li Z, Graham D, Taylor GW, Ellmerich S, Mangione PP, Tennent GA, Hutchinson WL, Millar DJ, Bennett G, More J, Evans D, Mistry Y, Poole S, Hawkins PN. Pepys MB, et al. Among authors: ellmerich s. J Immunol Methods. 2012 Oct 31;384(1-2):92-102. doi: 10.1016/j.jim.2012.07.013. Epub 2012 Jul 31. J Immunol Methods. 2012. PMID: 22867744 Free PMC article.
Pathogenetic mechanisms of amyloid A amyloidosis.
Simons JP, Al-Shawi R, Ellmerich S, Speck I, Aslam S, Hutchinson WL, Mangione PP, Disterer P, Gilbertson JA, Hunt T, Millar DJ, Minogue S, Bodin K, Pepys MB, Hawkins PN. Simons JP, et al. Among authors: ellmerich s. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16115-20. doi: 10.1073/pnas.1306621110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959890 Free PMC article.
C-reactive protein is essential for innate resistance to pneumococcal infection.
Simons JP, Loeffler JM, Al-Shawi R, Ellmerich S, Hutchinson WL, Tennent GA, Petrie A, Raynes JG, de Souza JB, Lawrence RA, Read KD, Pepys MB. Simons JP, et al. Among authors: ellmerich s. Immunology. 2014 Jul;142(3):414-20. doi: 10.1111/imm.12266. Immunology. 2014. PMID: 24673624 Free PMC article.
Bifunctional crosslinking ligands for transthyretin.
Mangione PP, Deroo S, Ellmerich S, Bellotti V, Kolstoe S, Wood SP, Robinson CV, Smith MD, Tennent GA, Broadbridge RJ, Council CE, Thurston JR, Steadman VA, Vong AK, Swain CJ, Pepys MB, Taylor GW. Mangione PP, et al. Among authors: ellmerich s. Open Biol. 2015 Sep;5(9):150105. doi: 10.1098/rsob.150105. Open Biol. 2015. PMID: 26400472 Free PMC article.
Amyloid persistence in decellularized liver: biochemical and histopathological characterization.
Mazza G, Simons JP, Al-Shawi R, Ellmerich S, Urbani L, Giorgetti S, Taylor GW, Gilbertson JA, Hall AR, Al-Akkad W, Dhar D, Hawkins PN, De Coppi P, Pinzani M, Bellotti V, Mangione PP. Mazza G, et al. Among authors: ellmerich s. Amyloid. 2016;23(1):1-7. doi: 10.3109/13506129.2015.1110518. Epub 2015 Dec 8. Amyloid. 2016. PMID: 26646718 Free PMC article.
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.
Izco M, Blesa J, Schleef M, Schmeer M, Porcari R, Al-Shawi R, Ellmerich S, de Toro M, Gardiner C, Seow Y, Reinares-Sebastian A, Forcen R, Simons JP, Bellotti V, Cooper JM, Alvarez-Erviti L. Izco M, et al. Among authors: ellmerich s. Mol Ther. 2019 Dec 4;27(12):2111-2122. doi: 10.1016/j.ymthe.2019.08.010. Epub 2019 Aug 27. Mol Ther. 2019. PMID: 31501034 Free PMC article.
24 results