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Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop.
Ellison CA, Blackburn KL, Carmichael PL, Clewell HJ 3rd, Cronin MTD, Desprez B, Escher SE, Ferguson SS, Grégoire S, Hewitt NJ, Hollnagel HM, Klaric M, Patel A, Salhi S, Schepky A, Schmitt BG, Wambaugh JF, Worth A. Ellison CA, et al. Regul Toxicol Pharmacol. 2019 Apr;103:63-72. doi: 10.1016/j.yrtph.2019.01.016. Epub 2019 Jan 15. Regul Toxicol Pharmacol. 2019. PMID: 30653989 Free PMC article. Review.
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme.
Desprez B, Dent M, Keller D, Klaric M, Ouédraogo G, Cubberley R, Duplan H, Eilstein J, Ellison C, Grégoire S, Hewitt NJ, Jacques-Jamin C, Lange D, Roe A, Rothe H, Blaauboer BJ, Schepky A, Mahony C. Desprez B, et al. Toxicol In Vitro. 2018 Aug;50:137-146. doi: 10.1016/j.tiv.2018.02.017. Epub 2018 Mar 2. Toxicol In Vitro. 2018. PMID: 29499337 Review.
Comparison of the metabolism of 10 chemicals in human and pig skin explants.
Géniès C, Jamin EL, Debrauwer L, Zalko D, Person EN, Eilstein J, Grégoire S, Schepky A, Lange D, Ellison C, Roe A, Salhi S, Cubberley R, Hewitt NJ, Rothe H, Klaric M, Duplan H, Jacques-Jamin C. Géniès C, et al. J Appl Toxicol. 2019 Feb;39(2):385-397. doi: 10.1002/jat.3730. Epub 2018 Oct 21. J Appl Toxicol. 2019. PMID: 30345528 Free PMC article.
Measurement of the penetration of 56 cosmetic relevant chemicals into and through human skin using a standardized protocol.
Hewitt NJ, Grégoire S, Cubberley R, Duplan H, Eilstein J, Ellison C, Lester C, Fabian E, Fernandez J, Géniès C, Jacques-Jamin C, Klaric M, Rothe H, Sorrell I, Lange D, Schepky A. Hewitt NJ, et al. J Appl Toxicol. 2020 Mar;40(3):403-415. doi: 10.1002/jat.3913. Epub 2019 Dec 22. J Appl Toxicol. 2020. PMID: 31867769 Free PMC article.
Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics-relevant chemicals.
Eilstein J, Grégoire S, Fabre A, Arbey E, Géniès C, Duplan H, Rothe H, Ellison C, Cubberley R, Schepky A, Lange D, Klaric M, Hewitt NJ, Jacques-Jamin C. Eilstein J, et al. J Appl Toxicol. 2020 Mar;40(3):416-433. doi: 10.1002/jat.3914. Epub 2020 Jan 8. J Appl Toxicol. 2020. PMID: 31912921
The way forward for assessing the human health safety of cosmetics in the EU - Workshop proceedings.
Rogiers V, Benfenati E, Bernauer U, Bodin L, Carmichael P, Chaudhry Q, Coenraads PJ, Cronin MTD, Dent M, Dusinska M, Ellison C, Ezendam J, Gaffet E, Galli CL, Goebel C, Granum B, Hollnagel HM, Kern PS, Kosemund-Meynen K, Ouédraogo G, Panteri E, Rousselle C, Stepnik M, Vanhaecke T, von Goetz N, Worth A. Rogiers V, et al. Toxicology. 2020 Apr 30;436:152421. doi: 10.1016/j.tox.2020.152421. Epub 2020 Feb 28. Toxicology. 2020. PMID: 32119890
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