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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
Kilpeläinen TO, Carli JF, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW, Hayes JE, Zhao J, Pers TH, Schick U, Grarup N, Kutalik Z, Trompet S, Mangino M, Kristiansson K, Beekman M, Lyytikäinen LP, Eriksson J, Henneman P, Lahti J, Tanaka T, Luan J, Del Greco M F, Pasko D, Renström F, Willems SM, Mahajan A, Rose LM, Guo X, Liu Y, Kleber ME, Pérusse L, Gaunt T, Ahluwalia TS, Ju Sung Y, Ramos YF, Amin N, Amuzu A, Barroso I, Bellis C, Blangero J, Buckley BM, Böhringer S, I Chen YD, de Craen AJ, Crosslin DR, Dale CE, Dastani Z, Day FR, Deelen J, Delgado GE, Demirkan A, Finucane FM, Ford I, Garcia ME, Gieger C, Gustafsson S, Hallmans G, Hankinson SE, Havulinna AS, Herder C, Hernandez D, Hicks AA, Hunter DJ, Illig T, Ingelsson E, Ioan-Facsinay A, Jansson JO, Jenny NS, Jørgensen ME, Jørgensen T, Karlsson M, Koenig W, Kraft P, Kwekkeboom J, Laatikainen T, Ladwig KH, LeDuc CA, Lowe G, Lu Y, Marques-Vidal P, Meisinger C, Menni C, Morris AP, Myers RH, Männistö S, Nalls MA, Paternoster L, Peters A, Pradhan AD, Rankinen T, Rasmussen-Torvik LJ, Rathmann W, Rice TK, Brent Richards J, Ridker PM, Sattar N, Savage DB, Söderberg S, Timpson NJ, Vandenput L, van Heemst D, Uh HW, Vohl M… See abstract for full author list ➔ Kilpeläinen TO, et al. Among authors: eline slagboom p. Nat Commun. 2016 Feb 1;7:10494. doi: 10.1038/ncomms10494. Nat Commun. 2016. PMID: 26833098 Free PMC article.
Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels.
van Leeuwen EM, Karssen LC, Deelen J, Isaacs A, Medina-Gomez C, Mbarek H, Kanterakis A, Trompet S, Postmus I, Verweij N, van Enckevort DJ, Huffman JE, White CC, Feitosa MF, Bartz TM, Manichaikul A, Joshi PK, Peloso GM, Deelen P, van Dijk F, Willemsen G, de Geus EJ, Milaneschi Y, Penninx BW, Francioli LC, Menelaou A, Pulit SL, Rivadeneira F, Hofman A, Oostra BA, Franco OH, Mateo Leach I, Beekman M, de Craen AJ, Uh HW, Trochet H, Hocking LJ, Porteous DJ, Sattar N, Packard CJ, Buckley BM, Brody JA, Bis JC, Rotter JI, Mychaleckyj JC, Campbell H, Duan Q, Lange LA, Wilson JF, Hayward C, Polasek O, Vitart V, Rudan I, Wright AF, Rich SS, Psaty BM, Borecki IB, Kearney PM, Stott DJ, Adrienne Cupples L; Genome of The Netherlands Consortium; Jukema JW, van der Harst P, Sijbrands EJ, Hottenga JJ, Uitterlinden AG, Swertz MA, van Ommen GJ, de Bakker PI, Eline Slagboom P, Boomsma DI, Wijmenga C, van Duijn CM. van Leeuwen EM, et al. Among authors: eline slagboom p. Nat Commun. 2015 Mar 9;6:6065. doi: 10.1038/ncomms7065. Nat Commun. 2015. PMID: 25751400 Free PMC article.
Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium.
van der Spek A, Broer L, Draisma HHM, Pool R, Albrecht E, Beekman M, Mangino M, Raag M, Nyholt DR, Dharuri HK, Codd V, Amin N, de Geus EJC, Deelen J, Demirkan A, Yet I, Fischer K, Haller T, Henders AK, Isaacs A, Medland SE, Montgomery GW, Mooijaart SP, Strauch K, Suchiman HED, Vaarhorst AAM, van Heemst D, Wang-Sattler R, Whitfield JB, Willemsen G, Wright MJ, Martin NG, Samani NJ, Metspalu A, Eline Slagboom P, Spector TD, Boomsma DI, van Duijn CM, Gieger C. van der Spek A, et al. Among authors: eline slagboom p. Sci Rep. 2019 Aug 12;9(1):11623. doi: 10.1038/s41598-019-47282-6. Sci Rep. 2019. PMID: 31406173 Free PMC article.
Variation in the SHC1 gene and longevity in humans.
Mooijaart SP, van Heemst D, Schreuder J, van Gerwen S, Beekman M, Brandt BW, Eline Slagboom P, Westendorp RG; 'Long Life' Study Group. Mooijaart SP, et al. Among authors: eline slagboom p. Exp Gerontol. 2004 Feb;39(2):263-8. doi: 10.1016/j.exger.2003.10.001. Exp Gerontol. 2004. PMID: 15036421
DNA methylation signatures link prenatal famine exposure to growth and metabolism.
Tobi EW, Goeman JJ, Monajemi R, Gu H, Putter H, Zhang Y, Slieker RC, Stok AP, Thijssen PE, Müller F, van Zwet EW, Bock C, Meissner A, Lumey LH, Eline Slagboom P, Heijmans BT. Tobi EW, et al. Among authors: eline slagboom p. Nat Commun. 2014 Nov 26;5:5592. doi: 10.1038/ncomms6592. Nat Commun. 2014. PMID: 25424739 Free PMC article.
Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes.
Thijssen PE, Tobi EW, Balog J, Schouten SG, Kremer D, El Bouazzaoui F, Henneman P, Putter H, Eline Slagboom P, Heijmans BT, van der Maarel SM. Thijssen PE, et al. Among authors: eline slagboom p. Epigenetics. 2013 May;8(5):512-21. doi: 10.4161/epi.24450. Epub 2013 Apr 17. Epigenetics. 2013. PMID: 23644601 Free PMC article.
The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific.
Raule N, Sevini F, Li S, Barbieri A, Tallaro F, Lomartire L, Vianello D, Montesanto A, Moilanen JS, Bezrukov V, Blanché H, Hervonen A, Christensen K, Deiana L, Gonos ES, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Eline Slagboom P, Spazzafumo L, Antonietta Stazi M, Toussaint O, Vaupel JW, Rose G, Majamaa K, Perola M, Johnson TE, Bolund L, Yang H, Passarino G, Franceschi C. Raule N, et al. Among authors: eline slagboom p. Aging Cell. 2014 Jun;13(3):401-7. doi: 10.1111/acel.12186. Epub 2013 Dec 17. Aging Cell. 2014. PMID: 24341918 Free PMC article.
15 results