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Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.
Bacos K, Perfilyev A, Karagiannopoulos A, Cowan E, Ofori JK, Bertonnier-Brouty L, Rönn T, Lindqvist A, Luan C, Ruhrmann S, Ngara M, Nilsson Å, Gheibi S, Lyons CL, Lagerstedt JO, Barghouth M, Esguerra JL, Volkov P, Fex M, Mulder H, Wierup N, Krus U, Artner I, Eliasson L, Prasad RB, Cataldo LR, Ling C. Bacos K, et al. Among authors: eliasson l. J Clin Invest. 2023 Feb 15;133(4):e163612. doi: 10.1172/JCI163612. J Clin Invest. 2023. PMID: 36656641 Free PMC article.
Beta-cell PDE3B regulates Ca2+-stimulated exocytosis of insulin.
Walz HA, Wierup N, Vikman J, Manganiello VC, Degerman E, Eliasson L, Holst LS. Walz HA, et al. Among authors: eliasson l. Cell Signal. 2007 Jul;19(7):1505-13. doi: 10.1016/j.cellsig.2007.01.030. Epub 2007 Feb 12. Cell Signal. 2007. PMID: 17368848
Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
Andersson SA, Olsson AH, Esguerra JL, Heimann E, Ladenvall C, Edlund A, Salehi A, Taneera J, Degerman E, Groop L, Ling C, Eliasson L. Andersson SA, et al. Among authors: eliasson l. Mol Cell Endocrinol. 2012 Nov 25;364(1-2):36-45. doi: 10.1016/j.mce.2012.08.009. Epub 2012 Aug 23. Mol Cell Endocrinol. 2012. PMID: 22939844 Free article.
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes.
Mahdi T, Hänzelmann S, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JL, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH. Mahdi T, et al. Among authors: eliasson l. Cell Metab. 2012 Nov 7;16(5):625-33. doi: 10.1016/j.cmet.2012.10.009. Cell Metab. 2012. PMID: 23140642 Free article.
244 results