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Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët JF, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T. Sake SM, et al. Among authors: elgaher wam. Nat Commun. 2024 Feb 8;15(1):1173. doi: 10.1038/s41467-024-45241-y. Nat Commun. 2024. PMID: 38332002 Free PMC article. Review.
Revision of the Absolute Configurations of Chelocardin and Amidochelocardin.
Sikandar A, Popoff A, Jumde RP, Mándi A, Kaur A, Elgaher WAM, Rosenberger L, Hüttel S, Jansen R, Hunter M, Köhnke J, Hirsch AKH, Kurtán T, Müller R. Sikandar A, et al. Among authors: elgaher wam. Angew Chem Int Ed Engl. 2023 Oct 2;62(40):e202306437. doi: 10.1002/anie.202306437. Epub 2023 Aug 17. Angew Chem Int Ed Engl. 2023. PMID: 37466921
NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner.
Waqas FH, Shehata M, Elgaher WAM, Lacour A, Kurmasheva N, Begnini F, Kiib AE, Dahlmann J, Chen C, Pavlou A, Poulsen TB, Merkert S, Martin U, Olmer R, Olagnier D, Hirsch AKH, Pleschka S, Pessler F. Waqas FH, et al. Among authors: elgaher wam. PLoS Pathog. 2023 Jul 17;19(7):e1011506. doi: 10.1371/journal.ppat.1011506. eCollection 2023 Jul. PLoS Pathog. 2023. PMID: 37459366 Free PMC article.
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Chen F, et al. Among authors: elgaher wam. Nat Metab. 2022 May;4(5):534-546. doi: 10.1038/s42255-022-00577-x. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655026 Free PMC article.
Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization.
Della Volpe S, Linciano P, Listro R, Tumminelli E, Amadio M, Bonomo I, Elgaher WAM, Adam S, Hirsch AKH, Boeckler FM, Vasile F, Rossi D, Collina S. Della Volpe S, et al. Among authors: elgaher wam. Bioorg Chem. 2021 Nov;116:105305. doi: 10.1016/j.bioorg.2021.105305. Epub 2021 Aug 26. Bioorg Chem. 2021. PMID: 34482166
Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase.
Jumde RP, Guardigni M, Gierse RM, Alhayek A, Zhu D, Hamid Z, Johannsen S, Elgaher WAM, Neusens PJ, Nehls C, Haupenthal J, Reiling N, Hirsch AKH. Jumde RP, et al. Among authors: elgaher wam. Chem Sci. 2021 Apr 28;12(22):7775-7785. doi: 10.1039/d1sc00330e. Chem Sci. 2021. PMID: 34168831 Free PMC article.
A hydrogel-based in vitro assay for the fast prediction of antibiotic accumulation in Gram-negative bacteria.
Richter R, Kamal MAM, García-Rivera MA, Kaspar J, Junk M, Elgaher WAM, Srikakulam SK, Gress A, Beckmann A, Grißmer A, Meier C, Vielhaber M, Kalinina O, Hirsch AKH, Hartmann RW, Brönstrup M, Schneider-Daum N, Lehr CM. Richter R, et al. Among authors: elgaher wam. Mater Today Bio. 2020 Nov 2;8:100084. doi: 10.1016/j.mtbio.2020.100084. eCollection 2020 Sep. Mater Today Bio. 2020. PMID: 33313504 Free PMC article.
Evaluation of Bacterial RNA Polymerase Inhibitors in a Staphylococcus aureus-Based Wound Infection Model in SKH1 Mice.
Haupenthal J, Kautz Y, Elgaher WAM, Pätzold L, Röhrig T, Laschke MW, Tschernig T, Hirsch AKH, Molodtsov V, Murakami KS, Hartmann RW, Bischoff M. Haupenthal J, et al. Among authors: elgaher wam. ACS Infect Dis. 2020 Oct 9;6(10):2573-2581. doi: 10.1021/acsinfecdis.0c00034. Epub 2020 Sep 21. ACS Infect Dis. 2020. PMID: 32886885 Free PMC article.
20 results