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Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.
Maschalidi S, Mehrotra P, Keçeli BN, De Cleene HKL, Lecomte K, Van der Cruyssen R, Janssen P, Pinney J, van Loo G, Elewaut D, Massie A, Hoste E, Ravichandran KS. Maschalidi S, et al. Among authors: elewaut d. Nature. 2022 Jun;606(7915):776-784. doi: 10.1038/s41586-022-04754-6. Epub 2022 May 25. Nature. 2022. PMID: 35614212
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G. Matmati M, et al. Among authors: elewaut d. Nat Genet. 2011 Aug 14;43(9):908-12. doi: 10.1038/ng.874. Nat Genet. 2011. PMID: 21841782
Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis.
Vande Walle L, Van Opdenbosch N, Jacques P, Fossoul A, Verheugen E, Vogel P, Beyaert R, Elewaut D, Kanneganti TD, van Loo G, Lamkanfi M. Vande Walle L, et al. Among authors: elewaut d. Nature. 2014 Aug 7;512(7512):69-73. doi: 10.1038/nature13322. Epub 2014 Jun 29. Nature. 2014. PMID: 25043000 Free PMC article.
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis.
De Wilde K, Martens A, Lambrecht S, Jacques P, Drennan MB, Debusschere K, Govindarajan S, Coudenys J, Verheugen E, Windels F, Catrysse L, Lories R, McGonagle D, Beyaert R, van Loo G, Elewaut D. De Wilde K, et al. Among authors: elewaut d. Ann Rheum Dis. 2017 Mar;76(3):585-592. doi: 10.1136/annrheumdis-2016-209454. Epub 2016 Aug 22. Ann Rheum Dis. 2017. PMID: 27551052
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Govindarajan S, Gaublomme D, Van der Cruyssen R, Verheugen E, Van Gassen S, Saeys Y, Tavernier S, Iwawaki T, Bloch Y, Savvides SN, Lambrecht BN, Janssens S, Elewaut D, Drennan MB. Govindarajan S, et al. Among authors: elewaut d. Nat Commun. 2018 Dec 17;9(1):5340. doi: 10.1038/s41467-018-07758-x. Nat Commun. 2018. PMID: 30559399 Free PMC article.
ELMO1 signaling is a promoter of osteoclast function and bone loss.
Arandjelovic S, Perry JSA, Zhou M, Ceroi A, Smirnov I, Walk SF, Shankman LS, Cambré I, Onengut-Gumuscu S, Elewaut D, Conrads TP, Ravichandran KS. Arandjelovic S, et al. Among authors: elewaut d. Nat Commun. 2021 Aug 17;12(1):4974. doi: 10.1038/s41467-021-25239-6. Nat Commun. 2021. PMID: 34404802 Free PMC article.
A20 controls RANK-dependent osteoclast formation and bone physiology.
Martens A, Hertens P, Priem D, Rinotas V, Meletakos T, Gennadi M, Van Hove L, Louagie E, Coudenys J, De Muynck A, Gaublomme D, Sze M, van Hengel J, Catrysse L, Hoste E, Zajac JD, Davey RA, Van Hoorebeke L, Hochepied T, Bertrand MJM, Armaka M, Elewaut D, van Loo G. Martens A, et al. Among authors: elewaut d. EMBO Rep. 2022 Dec 6;23(12):e55233. doi: 10.15252/embr.202255233. Epub 2022 Oct 4. EMBO Rep. 2022. PMID: 36194667 Free PMC article.
Sterile triggers drive joint inflammation in TNF- and IL-1β-dependent mouse arthritis models.
Thiran A, Petta I, Blancke G, Thorp M, Planckaert G, Jans M, Andries V, Barbry K, Gilis E, Coudenys J, Hochepied T, Vanhove C, Gracey E, Dumas E, Manuelo T, Josipovic I, van Loo G, Elewaut D, Vereecke L. Thiran A, et al. Among authors: elewaut d. EMBO Mol Med. 2023 Oct 11;15(10):e17691. doi: 10.15252/emmm.202317691. Epub 2023 Sep 11. EMBO Mol Med. 2023. PMID: 37694693 Free PMC article.
355 results