Eldehna WM - Search Results

1

Role of MEK1 and DIAPH3 expression in colorectal adenoma-carcinoma sequence.

Foda AAM, El-Hawary AK, Elnaghi K, Eldehna WM, Enan ET. Foda AAM, et al. Among authors: eldehna wm. Tumour Biol. 2024;46(1):1-11. doi: 10.3233/TUB-230038. Tumour Biol. 2024. PMID: 38728194 Free article.

2

In vitro biological evaluation and in silico insights into the antiviral activity of standardized olive leaves extract against SARS-CoV-2.

Majrashi TA, El Hassab MA, Mahmoud SH, Mostafa A, Wahsh EA, Elkaeed EB, Hassan FE, Eldehna WM, Abdelgawad SM. Majrashi TA, et al. Among authors: eldehna wm. PLoS One. 2024 Apr 25;19(4):e0301086. doi: 10.1371/journal.pone.0301086. eCollection 2024. PLoS One. 2024. PMID: 38662719 Free PMC article.

3

Discovery and Mechanistic Studies of Dual-Target Hits for Carbonic Anhydrase IX and VEGFR-2 as Potential Agents for Solid Tumors: X-ray, In Vitro, In Vivo, and In Silico Investigations of Coumarin-Based Thiazoles.

Hefny SM, El-Moselhy TF, El-Din N, Giovannuzzi S, Bin Traiki T, Vaali-Mohammed MA, El-Dessouki AM, Yamaguchi K, Sugiura M, Shaldam MA, Supuran CT, Abdulla MH, Eldehna WM, Tawfik HO. Hefny SM, et al. Among authors: eldehna wm. J Med Chem. 2024 May 9;67(9):7406-7430. doi: 10.1021/acs.jmedchem.4c00239. Epub 2024 Apr 20. J Med Chem. 2024. PMID: 38642371

4

DFT and molecular simulation validation of the binding activity of PDEδ inhibitors for repression of oncogenic k-Ras.

Majrashi TA, Sabt A, Almahli H, El Hassab MA, Noamaan MA, Elkaeed EB, Hamissa MF, Maslamani AN, Shaldam MA, Eldehna WM. Majrashi TA, et al. Among authors: eldehna wm. PLoS One. 2024 Mar 8;19(3):e0300035. doi: 10.1371/journal.pone.0300035. eCollection 2024. PLoS One. 2024. PMID: 38457483 Free PMC article.

5

Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction.

Gaber AA, Abo Elmaaty A, Sharaky M, Mosa AA, Yahya Abdullah Alzahrani A, Shaaban S, Eldehna WM, Al-Karmalawy AA. Gaber AA, et al. Among authors: eldehna wm. Bioorg Chem. 2024 Apr;145:107223. doi: 10.1016/j.bioorg.2024.107223. Epub 2024 Feb 17. Bioorg Chem. 2024. PMID: 38387399

6

New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAF^V600E/VEGFR-2 inhibition, and computational studies.

Sabt A, Khedr MA, Eldehna WM, Elshamy AI, Abdelhameed MF, Allam RM, Batran RZ. Sabt A, et al. Among authors: eldehna wm. RSC Adv. 2024 Feb 16;14(9):5907-5925. doi: 10.1039/d4ra00157e. eCollection 2024 Feb 14. RSC Adv. 2024. PMID: 38370458 Free PMC article.

7

An overview of recent advancements in small molecules suppression of oncogenic signaling of K-RAS: an updated review.

Sabt A, Tawfik HO, Khaleel EF, Badi RM, Ibrahim HAA, Elkaeed EB, Eldehna WM. Sabt A, et al. Among authors: eldehna wm. Mol Divers. 2024 Jan 30. doi: 10.1007/s11030-023-10777-6. Online ahead of print. Mol Divers. 2024. PMID: 38289431 Review.

8

Identification of new anti-mycobacterial agents based on quinoline-isatin hybrids targeting enoyl acyl carrier protein reductase (InhA).

Khaleel EF, Sabt A, Korycka-Machala M, Badi RM, Son NT, Ha NX, Hamissa MF, Elsawi AE, Elkaeed EB, Dziadek B, Eldehna WM, Dziadek J. Khaleel EF, et al. Among authors: eldehna wm. Bioorg Chem. 2024 Mar;144:107138. doi: 10.1016/j.bioorg.2024.107138. Epub 2024 Jan 20. Bioorg Chem. 2024. PMID: 38262087

9

1,2,4-Triazole-Tethered Indolinones as New Cancer-Fighting Small Molecules Targeting VEGFR-2: Synthesis, Biological Evaluations and Molecular Docking.

Elsawi AE, Shahin MI, Elbendary HA, Al-Warhi T, Hassan FE, Eldehna WM. Elsawi AE, et al. Among authors: eldehna wm. Pharmaceuticals (Basel). 2024 Jan 8;17(1):81. doi: 10.3390/ph17010081. Pharmaceuticals (Basel). 2024. PMID: 38256914 Free PMC article.

10

Discovery of Novel Pyridazine-Tethered Sulfonamides as Carbonic Anhydrase II Inhibitors for the Management of Glaucoma.

Tawfik HO, Saleh MM, Ammara A, Khaleel EF, Badi R, Khater YTT, Rasheed RA, Attia AA, Hefny SM, Elkaeed EB, Nocentini A, Supuran CT, Eldehna WM, Shaldam MA. Tawfik HO, et al. Among authors: eldehna wm. J Med Chem. 2024 Jan 25;67(2):1611-1623. doi: 10.1021/acs.jmedchem.3c02279. Epub 2024 Jan 11. J Med Chem. 2024. PMID: 38207099

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