Elbrecht A - Search Results

1

Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.

Shi GQ, Dropinski JF, McKeever BM, Xu S, Becker JW, Berger JP, MacNaul KL, Elbrecht A, Zhou G, Doebber TW, Wang P, Chao YS, Forrest M, Heck JV, Moller DE, Jones AB. Shi GQ, et al. Among authors: elbrecht a. J Med Chem. 2005 Jun 30;48(13):4457-68. doi: 10.1021/jm0502135. J Med Chem. 2005. PMID: 15974597

2

O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.

Adams AD, Hu Z, von Langen D, Dadiz A, Elbrecht A, MacNaul KL, Berger JP, Zhou G, Doebber TW, Meurer R, Forrest MJ, Moller DE, Jones AB. Adams AD, et al. Among authors: elbrecht a. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3185-90. doi: 10.1016/s0960-894x(03)00702-9. Bioorg Med Chem Lett. 2003. PMID: 12951090

3

Gene expression profile of adipocyte differentiation and its regulation by peroxisome proliferator-activated receptor-gamma agonists.

Gerhold DL, Liu F, Jiang G, Li Z, Xu J, Lu M, Sachs JR, Bagchi A, Fridman A, Holder DJ, Doebber TW, Berger J, Elbrecht A, Moller DE, Zhang BB. Gerhold DL, et al. Among authors: elbrecht a. Endocrinology. 2002 Jun;143(6):2106-18. doi: 10.1210/endo.143.6.8842. Endocrinology. 2002. PMID: 12021175

4

A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a).

Menke JG, Macnaul KL, Hayes NS, Baffic J, Chao YS, Elbrecht A, Kelly LJ, Lam MH, Schmidt A, Sahoo S, Wang J, Wright SD, Xin P, Zhou G, Moller DE, Sparrow CP. Menke JG, et al. Among authors: elbrecht a. Endocrinology. 2002 Jul;143(7):2548-58. doi: 10.1210/endo.143.7.8907. Endocrinology. 2002. PMID: 12072387

5

Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator.

Berger JP, Petro AE, Macnaul KL, Kelly LJ, Zhang BB, Richards K, Elbrecht A, Johnson BA, Zhou G, Doebber TW, Biswas C, Parikh M, Sharma N, Tanen MR, Thompson GM, Ventre J, Adams AD, Mosley R, Surwit RS, Moller DE. Berger JP, et al. Among authors: elbrecht a. Mol Endocrinol. 2003 Apr;17(4):662-76. doi: 10.1210/me.2002-0217. Epub 2003 Jan 16. Mol Endocrinol. 2003. PMID: 12554792

6

Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.

Berger J, Leibowitz MD, Doebber TW, Elbrecht A, Zhang B, Zhou G, Biswas C, Cullinan CA, Hayes NS, Li Y, Tanen M, Ventre J, Wu MS, Berger GD, Mosley R, Marquis R, Santini C, Sahoo SP, Tolman RL, Smith RG, Moller DE. Berger J, et al. Among authors: elbrecht a. J Biol Chem. 1999 Mar 5;274(10):6718-25. doi: 10.1074/jbc.274.10.6718. J Biol Chem. 1999. PMID: 10037770 Free article.

7

L-764406 is a partial agonist of human peroxisome proliferator-activated receptor gamma. The role of Cys313 in ligand binding.

Elbrecht A, Chen Y, Adams A, Berger J, Griffin P, Klatt T, Zhang B, Menke J, Zhou G, Smith RG, Moller DE. Elbrecht A, et al. J Biol Chem. 1999 Mar 19;274(12):7913-22. doi: 10.1074/jbc.274.12.7913. J Biol Chem. 1999. PMID: 10075686 Free article.

8

Peroxisome proliferator-activated receptor-gamma ligands inhibit adipocyte 11beta -hydroxysteroid dehydrogenase type 1 expression and activity.

Berger J, Tanen M, Elbrecht A, Hermanowski-Vosatka A, Moller DE, Wright SD, Thieringer R. Berger J, et al. Among authors: elbrecht a. J Biol Chem. 2001 Apr 20;276(16):12629-35. doi: 10.1074/jbc.M003592200. Epub 2001 Jan 22. J Biol Chem. 2001. PMID: 11278270 Free article.

9

Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma.

Zhang B, Berger J, Zhou G, Elbrecht A, Biswas S, White-Carrington S, Szalkowski D, Moller DE. Zhang B, et al. Among authors: elbrecht a. J Biol Chem. 1996 Dec 13;271(50):31771-4. doi: 10.1074/jbc.271.50.31771. J Biol Chem. 1996. PMID: 8943212 Free article.

10

PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver.

Hermanowski-Vosatka A, Gerhold D, Mundt SS, Loving VA, Lu M, Chen Y, Elbrecht A, Wu M, Doebber T, Kelly L, Milot D, Guo Q, Wang PR, Ippolito M, Chao YS, Wright SD, Thieringer R. Hermanowski-Vosatka A, et al. Among authors: elbrecht a. Biochem Biophys Res Commun. 2000 Dec 20;279(2):330-6. doi: 10.1006/bbrc.2000.3966. Biochem Biophys Res Commun. 2000. PMID: 11118287

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