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4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments.
Ragab MA, Eldehna WM, Nocentini A, Bonardi A, Okda HE, Elgendy B, Ibrahim TS, Abd-Alhaseeb MM, Gratteri P, Supuran CT, Al-Karmalawy AA, Elagawany M. Ragab MA, et al. Among authors: elagawany m. Eur J Med Chem. 2023 Mar 15;250:115180. doi: 10.1016/j.ejmech.2023.115180. Epub 2023 Feb 3. Eur J Med Chem. 2023. PMID: 36796297
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.
Badawi WA, Rashed M, Nocentini A, Bonardi A, Abd-Alhaseeb MM, Al-Rashood ST, Veerakanellore GB, Majrashi TA, Elkaeed EB, Elgendy B, Gratteri P, Supuran CT, Eldehna WM, Elagawany M. Badawi WA, et al. Among authors: elagawany m. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407. doi: 10.1080/14756366.2023.2201407. J Enzyme Inhib Med Chem. 2023. PMID: 37078173 Free PMC article.
Traceless chemical ligations from O-acyl serine sites.
El Khatib M, Elagawany M, Jabeen F, Todadze E, Bol'shakov O, Oliferenko A, Khelashvili L, el-Feky SA, Asiri A, Katritzky AR. El Khatib M, et al. Among authors: elagawany m. Org Biomol Chem. 2012 Jul 7;10(25):4836-8. doi: 10.1039/c2ob07050b. Epub 2012 May 28. Org Biomol Chem. 2012. PMID: 22635203
Total synthesis of cyclic heptapeptide Rolloamide B.
El Khatib M, Elagawany M, Çalışkan E, Davis EF, Faidallah HM, El-feky SA, Katritzky AR. El Khatib M, et al. Among authors: elagawany m. Chem Commun (Camb). 2013 Apr 4;49(26):2631-3. doi: 10.1039/c3cc39291k. Chem Commun (Camb). 2013. PMID: 23435737
Synthesis and antiproliferative effects of 5,6-disubstituted Pyridazin-3(2H)-ones designed as conformationally constrained combretastatin A-4 Analogues.
Elagawany M, Schmitt M, Ghiaty A, El-Etrawy ASh, Ibrahim MA, Bihel F, Sbardelotto AB, Pessoa C, Nguyen TL, Hamel E, Bourguignon JJ. Elagawany M, et al. Anticancer Agents Med Chem. 2013 Sep;13(7):1133-40. doi: 10.2174/1871520611313070018. Anticancer Agents Med Chem. 2013. PMID: 23574386 Free PMC article.
Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.
Ibrahim TS, Bokhtia RM, Al-Mahmoudy AMM, Taher ES, AlAwadh MA, Elagawany M, Abdel-Aal EH, Panda S, Gouda AM, Asfour HZ, Alhakamy NA, Youssif BGM. Ibrahim TS, et al. Among authors: elagawany m. Bioorg Chem. 2020 Jun;99:103782. doi: 10.1016/j.bioorg.2020.103782. Epub 2020 Mar 24. Bioorg Chem. 2020. PMID: 32229348
30 results