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Reactive oxygen/nitrogen species contribute substantially to the antileukemia effect of APO866, a NAD lowering agent.
Cloux AJ, Aubry D, Heulot M, Widmann C, ElMokh O, Piacente F, Cea M, Nencioni A, Bellotti A, Bouzourène K, Pellegrin M, Mazzolai L, Duchosal MA, Nahimana A. Cloux AJ, et al. Among authors: elmokh o. Oncotarget. 2019 Nov 19;10(62):6723-6738. doi: 10.18632/oncotarget.27336. eCollection 2019 Nov 19. Oncotarget. 2019. PMID: 31803365 Free PMC article.
Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia.
ElMokh O, Matsumoto S, Biniecka P, Bellotti A, Schaeuble K, Piacente F, Gallart-Ayala H, Ivanisevic J, Stamenkovic I, Nencioni A, Nahimana A, Duchosal MA. ElMokh O, et al. Cell Death Dis. 2022 Apr 8;13(4):320. doi: 10.1038/s41419-022-04763-3. Cell Death Dis. 2022. PMID: 35396381 Free PMC article.