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The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.
Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. Bibo-Verdugo B, et al. ACS Infect Dis. 2019 Oct 11;5(10):1802-1812. doi: 10.1021/acsinfecdis.9b00237. Epub 2019 Aug 12. ACS Infect Dis. 2019. PMID: 31355632 Free PMC article.
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.
Long T, Rojo-Arreola L, Shi D, El-Sakkary N, Jarnagin K, Rock F, Meewan M, Rascón AA Jr, Lin L, Cunningham KA, Lemieux GA, Podust L, Abagyan R, Ashrafi K, McKerrow JH, Caffrey CR. Long T, et al. PLoS Negl Trop Dis. 2017 Jul 13;11(7):e0005680. doi: 10.1371/journal.pntd.0005680. eCollection 2017 Jul. PLoS Negl Trop Dis. 2017. PMID: 28704396 Free PMC article.
Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni.
Buskes MJ, Clements M, Bachovchin KA, Jalani HB, Leonard A, Bag S, Klug DM, Singh B, Campbell RF, Sciotti RJ, El-Sakkary N, Caffrey CR, Pollastri MP, Ferrins L. Buskes MJ, et al. Among authors: el sakkary n. ACS Med Chem Lett. 2020 Jan 10;11(3):258-265. doi: 10.1021/acsmedchemlett.9b00455. eCollection 2020 Mar 12. ACS Med Chem Lett. 2020. PMID: 32184954 Free PMC article.
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta AP, Skinner DE, El-Sakkary N, Momper JD, Gangoiti J, Dong Y, Vennerstrom JL, Charman SA, Caffrey CR, Keiser J. Probst A, et al. Among authors: el sakkary n. J Antimicrob Chemother. 2020 Oct 1;75(10):2925-2932. doi: 10.1093/jac/dkaa247. J Antimicrob Chemother. 2020. PMID: 32617557 Free PMC article.
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.
Monti L, Cornec AS, Oukoloff K, Kovalevich J, Prijs K, Alle T, Brunden KR, Smith AB 3rd, El-Sakkary N, Liu LJ, Syed A, Skinner DE, Ballatore C, Caffrey CR. Monti L, et al. Among authors: el sakkary n. ACS Infect Dis. 2021 May 14;7(5):1089-1103. doi: 10.1021/acsinfecdis.0c00508. Epub 2020 Oct 31. ACS Infect Dis. 2021. PMID: 33135408 Free PMC article.
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
Klug DM, Mavrogiannaki EM, Forbes KC, Silva L, Diaz-Gonzalez R, Pérez-Moreno G, Ceballos-Pérez G, Garcia-Hernández R, Bosch-Navarrete C, Cordón-Obras C, Gómez-Liñán C, Saura A, Momper JD, Martinez-Martinez MS, Manzano P, Syed A, El-Sakkary N, Caffrey CR, Gamarro F, Ruiz-Perez LM, Gonzalez Pacanowska D, Ferrins L, Navarro M, Pollastri MP. Klug DM, et al. Among authors: el sakkary n. J Med Chem. 2021 Jul 8;64(13):9404-9430. doi: 10.1021/acs.jmedchem.1c00674. Epub 2021 Jun 22. J Med Chem. 2021. PMID: 34156862 Free PMC article.
17 results