El-Helby AAH - Search Results

1

Design, synthesis and evaluation of new quinazolin-4-one derivatives as apoptotic enhancers and autophagy inhibitors with potent antitumor activity.

ElZahabi HSA, Nafie MS, Osman D, Elghazawy NH, Soliman DH, El-Helby AAH, Arafa RK. ElZahabi HSA, et al. Among authors: el helby aah. Eur J Med Chem. 2021 Oct 15;222:113609. doi: 10.1016/j.ejmech.2021.113609. Epub 2021 Jun 5. Eur J Med Chem. 2021. PMID: 34119830

2

Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors.

El-Adl K, El-Helby AA, Ayyad RR, Mahdy HA, Khalifa MM, Elnagar HA, Mehany ABM, Metwaly AM, Elhendawy MA, Radwan MM, ElSohly MA, Eissa IH. El-Adl K, et al. Bioorg Med Chem. 2021 Jan 1;29:115872. doi: 10.1016/j.bmc.2020.115872. Epub 2020 Nov 12. Bioorg Med Chem. 2021. PMID: 33214036

3

Discovery of new quinazolin-4(3H)-ones as VEGFR-2 inhibitors: Design, synthesis, and anti-proliferative evaluation.

Eissa IH, El-Helby AA, Mahdy HA, Khalifa MM, Elnagar HA, Mehany ABM, Metwaly AM, Elhendawy MA, Radwan MM, ElSohly MA, El-Adl K. Eissa IH, et al. Bioorg Chem. 2020 Dec;105:104380. doi: 10.1016/j.bioorg.2020.104380. Epub 2020 Oct 15. Bioorg Chem. 2020. PMID: 33128967

4

Design, Synthesis, In Vitro Anti-cancer Activity, ADMET Profile and Molecular Docking of Novel Triazolo[3,4-a]phthalazine Derivatives Targeting VEGFR-2 Enzyme.

El-Helby AA, Sakr H, Ayyad RRA, El-Adl K, Ali MM, Khedr F. El-Helby AA, et al. Anticancer Agents Med Chem. 2018;18(8):1184-1196. doi: 10.2174/1871520618666180412123833. Anticancer Agents Med Chem. 2018. PMID: 29651967

5

Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors.

El-Helby AA, Sakr H, Ayyad RR, Mahdy HA, Khalifa MM, Belal A, Rashed M, El-Sharkawy A, Metwaly AM, Elhendawy MA, Radwan MM, ElSohly MA, Eissa IH. El-Helby AA, et al. Bioorg Chem. 2020 Oct;103:104233. doi: 10.1016/j.bioorg.2020.104233. Epub 2020 Aug 26. Bioorg Chem. 2020. PMID: 32882440

6

Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.

El-Adl K, El-Helby AA, Sakr H, Elwan A. El-Adl K, et al. Bioorg Chem. 2020 Dec;105:104399. doi: 10.1016/j.bioorg.2020.104399. Epub 2020 Oct 21. Bioorg Chem. 2020. PMID: 33113414

7

Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations.

Elwan A, Sakr H, El-Helby AA, El-Morsy A, Abdelgawad MA, Ghoneim MM, El-Sherbiny M, El-Adl K. Elwan A, et al. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1556-1567. doi: 10.1080/14756366.2022.2080205. J Enzyme Inhib Med Chem. 2022. PMID: 35635148 Free PMC article.

8

Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR-2 inhibitors.

El-Helby AA, Sakr H, Eissa IH, Abulkhair H, Al-Karmalawy AA, El-Adl K. El-Helby AA, et al. Arch Pharm (Weinheim). 2019 Oct;352(10):e1900113. doi: 10.1002/ardp.201900113. Epub 2019 Aug 25. Arch Pharm (Weinheim). 2019. PMID: 31448458

9

Design, synthesis, molecular docking and anticancer evaluations of 5-benzylidenethiazolidine-2,4-dione derivatives targeting VEGFR-2 enzyme.

El-Adl K, El-Helby AA, Sakr H, Eissa IH, El-Hddad SSA, M I A Shoman F. El-Adl K, et al. Bioorg Chem. 2020 Sep;102:104059. doi: 10.1016/j.bioorg.2020.104059. Epub 2020 Jun 30. Bioorg Chem. 2020. PMID: 32653608

10

Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors.

El-Helby AA, Ayyad RRA, Sakr H, El-Adl K, Ali MM, Khedr F. El-Helby AA, et al. Arch Pharm (Weinheim). 2017 Dec;350(12). doi: 10.1002/ardp.201700240. Epub 2017 Nov 13. Arch Pharm (Weinheim). 2017. PMID: 29131379

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