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Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3.
Ansideri F, Macedo JT, Eitel M, El-Gokha A, Zinad DS, Scarpellini C, Kudolo M, Schollmeyer D, Boeckler FM, Blaum BS, Laufer SA, Koch P. Ansideri F, et al. Among authors: el gokha a. ACS Omega. 2018 Jul 31;3(7):7809-7831. doi: 10.1021/acsomega.8b00668. Epub 2018 Jul 12. ACS Omega. 2018. PMID: 30087925 Free PMC article.
Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors.
Andreev S, Pantsar T, Tesch R, Kahlke N, El-Gokha A, Ansideri F, Grätz L, Romasco J, Sita G, Geibel C, Lämmerhofer M, Tarozzi A, Knapp S, Laufer SA, Koch P. Andreev S, et al. Among authors: el gokha a. J Med Chem. 2022 Jan 27;65(2):1283-1301. doi: 10.1021/acs.jmedchem.0c02146. Epub 2021 Jul 2. J Med Chem. 2022. PMID: 34213342
Synthesis, Biological Evaluation, and In Silico Studies of Novel Coumarin-Based 4H,5H-pyrano[3,2-c]chromenes as Potent β-Glucuronidase and Carbonic Anhydrase Inhibitors.
Arif N, Shafiq Z, Mahmood K, Rafiq M, Naz S, Shahzad SA, Farooq U, Bahkali AH, Elgorban AM, Yaqub M, El-Gokha A. Arif N, et al. Among authors: el gokha a. ACS Omega. 2022 Aug 4;7(32):28605-28617. doi: 10.1021/acsomega.2c03528. eCollection 2022 Aug 16. ACS Omega. 2022. PMID: 35990487 Free PMC article.
Cytotoxic Potential of Novel Quinoline Derivative: 11-(1,4-Bisaminopropylpiperazinyl)5-methyl-5H-indolo[2,3-b]quinoline against Different Cancer Cell Lines via Activation and Deactivation of the Expression of Some Proteins.
Abd Elrahman SF, Ahmed AAS, Abd Elsatar D, Elkady S, Elgendy A, Alnakeeb F, Elmongy EI, Henidi HA, El-Gendy SM, El Sayed IET, El-Gokha AA, Abd Eldaim MA. Abd Elrahman SF, et al. Among authors: el gokha aa. Int J Mol Sci. 2023 Sep 20;24(18):14336. doi: 10.3390/ijms241814336. Int J Mol Sci. 2023. PMID: 37762637 Free PMC article.
12 results