El Kerdawy AM - Search Results

1

Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies.

Abd El-Meguid EA, Naglah AM, Moustafa GO, Awad HM, El Kerdawy AM. Abd El-Meguid EA, et al. Among authors: el kerdawy am. Bioorg Med Chem Lett. 2022 Feb 15;58:128529. doi: 10.1016/j.bmcl.2022.128529. Epub 2022 Jan 7. Bioorg Med Chem Lett. 2022. PMID: 35007724 Review.

2

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.

Eldehna WM, Abou-Seri SM, El Kerdawy AM, Ayyad RR, Hamdy AM, Ghabbour HA, Ali MM, Abou El Ella DA. Eldehna WM, et al. Among authors: el kerdawy am. Eur J Med Chem. 2016 May 4;113:50-62. doi: 10.1016/j.ejmech.2016.02.029. Epub 2016 Feb 15. Eur J Med Chem. 2016. PMID: 26922228

3

Synthesis and molecular docking of new imidazoquinazolinones as analgesic agents and selective COX-2 inhibitors.

Hassanein HH, Georgey HH, Fouad MA, El Kerdawy AM, Said MF. Hassanein HH, et al. Among authors: el kerdawy am. Future Med Chem. 2017 Apr;9(6):553-578. doi: 10.4155/fmc-2016-0240. Epub 2017 Apr 10. Future Med Chem. 2017. PMID: 28394629

4

Design, synthesis, molecular docking and cytotoxic evaluation of novel 2-furybenzimidazoles as VEGFR-2 inhibitors.

Abdullaziz MA, Abdel-Mohsen HT, El Kerdawy AM, Ragab FAF, Ali MM, Abu-Bakr SM, Girgis AS, El Diwani HI. Abdullaziz MA, et al. Among authors: el kerdawy am, el diwani hi. Eur J Med Chem. 2017 Aug 18;136:315-329. doi: 10.1016/j.ejmech.2017.04.068. Epub 2017 Apr 26. Eur J Med Chem. 2017. PMID: 28505536

5

Design, synthesis, and molecular docking of novel indole scaffold-based VEGFR-2 inhibitors as targeted anticancer agents.

Roaiah HM, Ghannam IAY, Ali IH, El Kerdawy AM, Ali MM, Abbas SE, El-Nakkady SS. Roaiah HM, et al. Among authors: el kerdawy am, el nakkady ss. Arch Pharm (Weinheim). 2018 Feb;351(2). doi: 10.1002/ardp.201700299. Epub 2018 Jan 11. Arch Pharm (Weinheim). 2018. PMID: 29323750

6

Type IIA - Type IIB protein tyrosine kinase inhibitors hybridization as an efficient approach for potent multikinase inhibitor development: Design, synthesis, anti-proliferative activity, multikinase inhibitory activity and molecular modeling of novel indolinone-based ureides and amides.

Eldehna WM, El Kerdawy AM, Al-Ansary GH, Al-Rashood ST, Ali MM, Mahmoud AE. Eldehna WM, et al. Among authors: el kerdawy am. Eur J Med Chem. 2019 Feb 1;163:37-53. doi: 10.1016/j.ejmech.2018.11.061. Epub 2018 Nov 24. Eur J Med Chem. 2019. PMID: 30503942

7

New thiazol-hydrazono-coumarin hybrids targeting human cervical cancer cells: Synthesis, CDK2 inhibition, QSAR and molecular docking studies.

Abd El-Karim SS, Syam YM, El Kerdawy AM, Abdelghany TM. Abd El-Karim SS, et al. Among authors: el kerdawy am. Bioorg Chem. 2019 May;86:80-96. doi: 10.1016/j.bioorg.2019.01.026. Epub 2019 Jan 19. Bioorg Chem. 2019. PMID: 30685646

8

Receptor-based pharmacophore modeling, virtual screening, and molecular docking studies for the discovery of novel GSK-3β inhibitors.

El Kerdawy AM, Osman AA, Zaater MA. El Kerdawy AM, et al. J Mol Model. 2019 May 25;25(6):171. doi: 10.1007/s00894-019-4032-5. J Mol Model. 2019. PMID: 31129879

9

Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors.

Abdel-Mohsen HT, Omar MA, El Kerdawy AM, Mahmoud AEE, Ali MM, El Diwani HI. Abdel-Mohsen HT, et al. Among authors: el kerdawy am, el diwani hi. Eur J Med Chem. 2019 Oct 1;179:707-722. doi: 10.1016/j.ejmech.2019.06.063. Epub 2019 Jun 26. Eur J Med Chem. 2019. PMID: 31284081

10

Novel 2-arylbenzothiazole DNA gyrase inhibitors: Synthesis, antimicrobial evaluation, QSAR and molecular docking studies.

Ghannam IAY, Abd El-Meguid EA, Ali IH, Sheir DH, El Kerdawy AM. Ghannam IAY, et al. Among authors: el kerdawy am. Bioorg Chem. 2019 Dec;93:103373. doi: 10.1016/j.bioorg.2019.103373. Epub 2019 Oct 24. Bioorg Chem. 2019. PMID: 31698294

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