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Sphingosine 1-phosphate and cancer.
Pyne NJ, El Buri A, Adams DR, Pyne S. Pyne NJ, et al. Among authors: el buri a. Adv Biol Regul. 2018 May;68:97-106. doi: 10.1016/j.jbior.2017.09.006. Epub 2017 Sep 15. Adv Biol Regul. 2018. PMID: 28942351 Free article. Review.
The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts.
El Buri A, Adams DR, Smith D, Tate RJ, Mullin M, Pyne S, Pyne NJ. El Buri A, et al. Oncotarget. 2018 Jun 29;9(50):29453-29467. doi: 10.18632/oncotarget.25658. eCollection 2018 Jun 29. Oncotarget. 2018. PMID: 30034630 Free PMC article.