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Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides.
Bost JP, Ojansivu M, Munson MJ, Wesén E, Gallud A, Gupta D, Gustafsson O, Saher O, Rädler J, Higgins SG, Lehto T, Holme MN, Dahlén A, Engkvist O, Strömstedt PE, Andersson S, Edvard Smith CI, Stevens MM, Esbjörner EK, Collén A, El Andaloussi S. Bost JP, et al. Among authors: el andaloussi s. Commun Biol. 2022 Mar 1;5(1):185. doi: 10.1038/s42003-022-03132-2. Commun Biol. 2022. PMID: 35233031 Free PMC article.
Self-Assembly into Nanoparticles Is Essential for Receptor Mediated Uptake of Therapeutic Antisense Oligonucleotides.
Ezzat K, Aoki Y, Koo T, McClorey G, Benner L, Coenen-Stass A, O'Donovan L, Lehto T, Garcia-Guerra A, Nordin J, Saleh AF, Behlke M, Morris J, Goyenvalle A, Dugovic B, Leumann C, Gordon S, Gait MJ, El-Andaloussi S, Wood MJ. Ezzat K, et al. Among authors: el andaloussi s. Nano Lett. 2015 Jul 8;15(7):4364-73. doi: 10.1021/acs.nanolett.5b00490. Epub 2015 Jun 15. Nano Lett. 2015. PMID: 26042553 Free PMC article.
Peptides for nucleic acid delivery.
Lehto T, Ezzat K, Wood MJA, El Andaloussi S. Lehto T, et al. Among authors: el andaloussi s. Adv Drug Deliv Rev. 2016 Nov 15;106(Pt A):172-182. doi: 10.1016/j.addr.2016.06.008. Epub 2016 Jun 25. Adv Drug Deliv Rev. 2016. PMID: 27349594 Free article. Review.
Delivery is key: lessons learnt from developing splice-switching antisense therapies.
Godfrey C, Desviat LR, Smedsrød B, Piétri-Rouxel F, Denti MA, Disterer P, Lorain S, Nogales-Gadea G, Sardone V, Anwar R, El Andaloussi S, Lehto T, Khoo B, Brolin C, van Roon-Mom WM, Goyenvalle A, Aartsma-Rus A, Arechavala-Gomeza V. Godfrey C, et al. Among authors: el andaloussi s. EMBO Mol Med. 2017 May;9(5):545-557. doi: 10.15252/emmm.201607199. EMBO Mol Med. 2017. PMID: 28289078 Free PMC article. Review.
Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity.
Saher O, Rocha CSJ, Zaghloul EM, Wiklander OPB, Zamolo S, Heitz M, Ezzat K, Gupta D, Reymond JL, Zain R, Hollfelder F, Darbre T, Lundin KE, El Andaloussi S, Smith CIE. Saher O, et al. Among authors: el andaloussi s. Eur J Pharm Biopharm. 2018 Nov;132:29-40. doi: 10.1016/j.ejpb.2018.09.002. Epub 2018 Sep 4. Eur J Pharm Biopharm. 2018. PMID: 30193928
The viral protein corona directs viral pathogenesis and amyloid aggregation.
Ezzat K, Pernemalm M, Pålsson S, Roberts TC, Järver P, Dondalska A, Bestas B, Sobkowiak MJ, Levänen B, Sköld M, Thompson EA, Saher O, Kari OK, Lajunen T, Sverremark Ekström E, Nilsson C, Ishchenko Y, Malm T, Wood MJA, Power UF, Masich S, Lindén A, Sandberg JK, Lehtiö J, Spetz AL, El Andaloussi S. Ezzat K, et al. Among authors: el andaloussi s. Nat Commun. 2019 May 27;10(1):2331. doi: 10.1038/s41467-019-10192-2. Nat Commun. 2019. PMID: 31133680 Free PMC article.
130 results