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Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression.
Korhonen EA, Murtomäki A, Jha SK, Anisimov A, Pink A, Zhang Y, Stritt S, Liaqat I, Stanczuk L, Alderfer L, Sun Z, Kapiainen E, Singh A, Sultan I, Lantta A, Leppänen VM, Eklund L, He Y, Augustin HG, Vaahtomeri K, Saharinen P, Mäkinen T, Alitalo K. Korhonen EA, et al. Among authors: eklund l. J Clin Invest. 2022 Aug 1;132(15):e155478. doi: 10.1172/JCI155478. J Clin Invest. 2022. PMID: 35763346 Free PMC article.
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis.
Holopainen T, Saharinen P, D'Amico G, Lampinen A, Eklund L, Sormunen R, Anisimov A, Zarkada G, Lohela M, Heloterä H, Tammela T, Benjamin LE, Ylä-Herttuala S, Leow CC, Koh GY, Alitalo K. Holopainen T, et al. Among authors: eklund l. J Natl Cancer Inst. 2012 Mar 21;104(6):461-75. doi: 10.1093/jnci/djs009. Epub 2012 Feb 17. J Natl Cancer Inst. 2012. PMID: 22343031 Free PMC article.
Angiopoietin signaling in the vasculature.
Eklund L, Saharinen P. Eklund L, et al. Exp Cell Res. 2013 May 15;319(9):1271-80. doi: 10.1016/j.yexcr.2013.03.011. Epub 2013 Mar 13. Exp Cell Res. 2013. PMID: 23500414 Review.
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy.
D'Amico G, Korhonen EA, Anisimov A, Zarkada G, Holopainen T, Hägerling R, Kiefer F, Eklund L, Sormunen R, Elamaa H, Brekken RA, Adams RH, Koh GY, Saharinen P, Alitalo K. D'Amico G, et al. Among authors: eklund l. J Clin Invest. 2014 Feb;124(2):824-34. doi: 10.1172/JCI68897. Epub 2014 Jan 16. J Clin Invest. 2014. PMID: 24430181 Free PMC article.
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart.
Kivelä R, Bry M, Robciuc MR, Räsänen M, Taavitsainen M, Silvola JM, Saraste A, Hulmi JJ, Anisimov A, Mäyränpää MI, Lindeman JH, Eklund L, Hellberg S, Hlushchuk R, Zhuang ZW, Simons M, Djonov V, Knuuti J, Mervaala E, Alitalo K. Kivelä R, et al. Among authors: eklund l. EMBO Mol Med. 2014 Mar;6(3):307-21. doi: 10.1002/emmm.201303147. Epub 2014 Jan 21. EMBO Mol Med. 2014. PMID: 24448490 Free PMC article.
Endothelial destabilization by angiopoietin-2 via integrin β1 activation.
Hakanpaa L, Sipila T, Leppanen VM, Gautam P, Nurmi H, Jacquemet G, Eklund L, Ivaska J, Alitalo K, Saharinen P. Hakanpaa L, et al. Among authors: eklund l. Nat Commun. 2015 Jan 30;6:5962. doi: 10.1038/ncomms6962. Nat Commun. 2015. PMID: 25635707 Free PMC article.
312 results