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131 results

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In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma.
Whitehouse JP, Hii H, Mayoh C, Wong M, Ajuyah P, Barahona P, Cui L, Dholaria H, White CL, Buntine MK, Byrne J, Rodrigues da Silva K, Howlett M, Girard EJ, Tsoli M, Ziegler DS, Dyke JM, Lee S, Ekert PG, Cowley MJ, Gottardo NG, Endersby R. Whitehouse JP, et al. Among authors: ekert pg. Front Oncol. 2023 Mar 3;13:1123492. doi: 10.3389/fonc.2023.1123492. eCollection 2023. Front Oncol. 2023. PMID: 36937401 Free PMC article.
Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes.
Ajuyah P, Mayoh C, Lau LMS, Barahona P, Wong M, Chambers H, Valdes-Mora F, Senapati A, Gifford AJ, D'Arcy C, Hansford JR, Manoharan N, Nicholls W, Williams MM, Wood PJ, Cowley MJ, Tyrrell V, Haber M, Ekert PG, Ziegler DS, Khuong-Quang DA. Ajuyah P, et al. Among authors: ekert pg. Sci Rep. 2023 Mar 7;13(1):3775. doi: 10.1038/s41598-023-30395-4. Sci Rep. 2023. PMID: 36882456 Free PMC article.
Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.
Sun CX, Daniel P, Bradshaw G, Shi H, Loi M, Chew N, Parackal S, Tsui V, Liang Y, Koptyra M, Adjumain S, Sun C, Chong WC, Fernando D, Drinkwater C, Tourchi M, Habarakada D, Sooraj D, Carvalho D, Storm PB, Baubet V, Sayles LC, Fernandez E, Nguyen T, Pörksen M, Doan A, Crombie DE, Panday M, Zhukova N, Dun MD, Ludlow LE, Day B, Stringer BW, Neeman N, Rubens JA, Raabe EH, Vinci M, Tyrrell V, Fletcher JI, Ekert PG, Dumevska B, Ziegler DS, Tsoli M, Syed Sulaiman NF, Loh AHP, Low SYY, Sweet-Cordero EA, Monje M, Resnick A, Jones C, Downie P, Williams B, Rosenbluh J, Gough D, Cain JE, Firestein R. Sun CX, et al. Among authors: ekert pg. Cancer Cell. 2023 Apr 10;41(4):660-677.e7. doi: 10.1016/j.ccell.2023.03.007. Epub 2023 Mar 30. Cancer Cell. 2023. PMID: 37001527 Free article.
Functional precision medicine for pediatric cancers.
Dolman MEM, Ekert PG. Dolman MEM, et al. Among authors: ekert pg. Nat Med. 2024 Apr;30(4):940-941. doi: 10.1038/s41591-024-02863-5. Nat Med. 2024. PMID: 38605165 No abstract available.
A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax.
Kosasih HJ, Healey G, Brennan MS, Bjelosevic S, Sadras T, Jalud FB, Ibnat T, Ng AP, Mayoh C, Mao J, Tax G, Ludlow LEA, Johnstone RW, Herold MJ, Khaw SL, de Bock CE, Ekert PG. Kosasih HJ, et al. Among authors: ekert pg. Hemasphere. 2024 Feb 14;8(2):e1. doi: 10.1002/hem3.1. eCollection 2024 Feb. Hemasphere. 2024. PMID: 38435422 Free PMC article. No abstract available.
High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.
Mayoh C, Mao J, Xie J, Tax G, Chow SO, Cadiz R, Pazaky K, Barahona P, Ajuyah P, Trebilcock P, Malquori A, Gunther K, Avila A, Yun DY, Alfred S, Gopalakrishnan A, Kamili A, Wong M, Cowley MJ, Jessop S, Lau LMS, Trahair TN, Ziegler DS, Fletcher JI, Gifford AJ, Tsoli M, Marshall GM, Haber M, Tyrrell V, Failes TW, Arndt GM, Lock RB, Ekert PG, Dolman MEM. Mayoh C, et al. Among authors: ekert pg. Cancer Res. 2023 Aug 15;83(16):2716-2732. doi: 10.1158/0008-5472.CAN-22-3702. Cancer Res. 2023. PMID: 37523146 Free PMC article.
Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.
Kan WL, Dhagat U, Kaufmann KB, Hercus TR, Nero TL, Zeng AGX, Toubia J, Barry EF, Broughton SE, Gomez GA, Benard BA, Dottore M, Cheung Tung Shing KS, Boutzen H, Samaraweera SE, Simpson KJ, Jin L, Goodall GJ, Begley CG, Thomas D, Ekert PG, Tvorogov D, D'Andrea RJ, Dick JE, Parker MW, Lopez AF. Kan WL, et al. Among authors: ekert pg. Cancer Discov. 2023 Aug 4;13(8):1922-1947. doi: 10.1158/2159-8290.CD-22-1396. Cancer Discov. 2023. PMID: 37191437 Free PMC article.
131 results