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Dual-Targeted Autoimmune Sword in Fatal Epilepsy: Patient's glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce Reactive Oxygen Species (ROS) in, and kill both human neural cells and T cells.
Levite M, Zelig D, Friedman A, Ilouz N, Eilam R, Bromberg Z, Ramadhan Lasu AA, Arbel-Alon S, Edvardson S, Tarshish M, Riek LP, Lako RL, Reubinoff B, Lebendiker M, Yaish D, Stavsky A, Galun E. Levite M, et al. Among authors: eilam r. J Autoimmun. 2020 Aug;112:102462. doi: 10.1016/j.jaut.2020.102462. Epub 2020 Apr 10. J Autoimmun. 2020. PMID: 32561150
Normal human CD4(+) helper T cells express Kv1.1 voltage-gated K(+) channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway.
Fellerhoff-Losch B, Korol SV, Ganor Y, Gu S, Cooper I, Eilam R, Besser M, Goldfinger M, Chowers Y, Wank R, Birnir B, Levite M. Fellerhoff-Losch B, et al. Among authors: eilam r. J Neural Transm (Vienna). 2016 Mar;123(3):137-57. doi: 10.1007/s00702-015-1446-9. Epub 2015 Nov 26. J Neural Transm (Vienna). 2016. PMID: 26611796
Age dependent course of EAE in Aire-/- mice.
Aharoni R, Aricha R, Eilam R, From I, Mizrahi K, Arnon R, Souroujon MC, Fuchs S. Aharoni R, et al. Among authors: eilam r. J Neuroimmunol. 2013 Sep 15;262(1-2):27-34. doi: 10.1016/j.jneuroim.2013.06.001. Epub 2013 Jul 9. J Neuroimmunol. 2013. PMID: 23849800
79 results