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A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice.
Alzheimers Res Ther. 2023 Jan 14;15(1):16. doi: 10.1186/s13195-022-01144-y.
Alzheimers Res Ther. 2023.
PMID: 36641439
Free PMC article.
Targeting isoaspartate-modified Aβ rescues behavioral deficits in transgenic mice with Alzheimer's disease-like pathology.
Gnoth K, Piechotta A, Kleinschmidt M, Konrath S, Schenk M, Taudte N, Ramsbeck D, Rieckmann V, Geissler S, Eichentopf R, Barendrecht S, Hartlage-Rübsamen M, Demuth HU, Roßner S, Cynis H, Rahfeld JU, Schilling S.
Gnoth K, et al. Among authors: eichentopf r.
Alzheimers Res Ther. 2020 Nov 14;12(1):149. doi: 10.1186/s13195-020-00719-x.
Alzheimers Res Ther. 2020.
PMID: 33189132
Free PMC article.
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Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.
Köppen J, Schulze A, Machner L, Wermann M, Eichentopf R, Guthardt M, Hähnel A, Klehm J, Kriegeskorte MC, Hartlage-Rübsamen M, Morawski M, von Hörsten S, Demuth HU, Roßner S, Schilling S.
Köppen J, et al. Among authors: eichentopf r.
Molecules. 2020 Jan 29;25(3):580. doi: 10.3390/molecules25030580.
Molecules. 2020.
PMID: 32013170
Free PMC article.
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Purification of recombinant Aβ(1-42) and pGlu-Aβ(3-42) using preparative SDS-PAGE.
Spahn C, Wermann M, Eichentopf R, Hause G, Schlenzig D, Schilling S.
Spahn C, et al. Among authors: eichentopf r.
Electrophoresis. 2017 Aug;38(16):2042-2049. doi: 10.1002/elps.201700154. Epub 2017 Jun 8.
Electrophoresis. 2017.
PMID: 28510356
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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S.
Becker A, et al. Among authors: eichentopf r.
Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192.
Biol Chem. 2016.
PMID: 26351917
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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU.
Cynis H, et al. Among authors: eichentopf r.
EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20.
EMBO Mol Med. 2011.
PMID: 21774078
Free PMC article.
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Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU.
Schilling S, et al. Among authors: eichentopf r.
J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17.
J Biol Chem. 2011.
PMID: 21330373
Free PMC article.
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