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CD161 expression and regulation defines rapidly responding effector CD4+ T cells associated with improved survival in HPV16-associated tumors.
Duurland CL, Santegoets SJ, Abdulrahman Z, Loof NM, Sturm G, Wesselink TH, Arens R, Boekestijn S, Ehsan I, van Poelgeest MIE, Finotello F, Hackl H, Trajanoski Z, Ten Dijke P, Braud VM, Welters MJP, van der Burg SH. Duurland CL, et al. Among authors: ehsan i. J Immunother Cancer. 2022 Jan;10(1):e003995. doi: 10.1136/jitc-2021-003995. J Immunother Cancer. 2022. PMID: 35039463 Free PMC article.
Intratumoral HPV16-Specific T Cells Constitute a Type I-Oriented Tumor Microenvironment to Improve Survival in HPV16-Driven Oropharyngeal Cancer.
Welters MJP, Ma W, Santegoets SJAM, Goedemans R, Ehsan I, Jordanova ES, van Ham VJ, van Unen V, Koning F, van Egmond SI, Charoentong P, Trajanoski Z, van der Velden LA, van der Burg SH. Welters MJP, et al. Among authors: ehsan i. Clin Cancer Res. 2018 Feb 1;24(3):634-647. doi: 10.1158/1078-0432.CCR-17-2140. Epub 2017 Oct 10. Clin Cancer Res. 2018. PMID: 29018052
High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status.
Kortekaas KE, Santegoets SJ, Abdulrahman Z, van Ham VJ, van der Tol M, Ehsan I, van Doorn HC, Bosse T, van Poelgeest MIE, van der Burg SH. Kortekaas KE, et al. Among authors: ehsan i. J Immunother Cancer. 2019 Sep 3;7(1):236. doi: 10.1186/s40425-019-0712-z. J Immunother Cancer. 2019. PMID: 31481117 Free PMC article.
CD39 Identifies the CD4+ Tumor-Specific T-cell Population in Human Cancer.
Kortekaas KE, Santegoets SJ, Sturm G, Ehsan I, van Egmond SL, Finotello F, Trajanoski Z, Welters MJP, van Poelgeest MIE, van der Burg SH. Kortekaas KE, et al. Among authors: ehsan i. Cancer Immunol Res. 2020 Oct;8(10):1311-1321. doi: 10.1158/2326-6066.CIR-20-0270. Epub 2020 Aug 5. Cancer Immunol Res. 2020. PMID: 32759363
Primary vulvar squamous cell carcinomas with high T cell infiltration and active immune signaling are potential candidates for neoadjuvant PD-1/PD-L1 immunotherapy.
Kortekaas KE, Santegoets SJ, Tas L, Ehsan I, Charoentong P, van Doorn HC, van Poelgeest MIE, Mustafa DAM, van der Burg SH. Kortekaas KE, et al. Among authors: ehsan i. J Immunother Cancer. 2021 Oct;9(10):e003671. doi: 10.1136/jitc-2021-003671. J Immunother Cancer. 2021. PMID: 34716208 Free PMC article.
HPV16 E7 DNA tattooing: safety, immunogenicity, and clinical response in patients with HPV-positive vulvar intraepithelial neoplasia.
Samuels S, Marijne Heeren A, Zijlmans HJMAA, Welters MJP, van den Berg JH, Philips D, Kvistborg P, Ehsan I, Scholl SME, Nuijen B, Schumacher TNM, van Beurden M, Jordanova ES, Haanen JBAG, van der Burg SH, Kenter GG. Samuels S, et al. Among authors: ehsan i. Cancer Immunol Immunother. 2017 Sep;66(9):1163-1173. doi: 10.1007/s00262-017-2006-y. Epub 2017 Apr 27. Cancer Immunol Immunother. 2017. PMID: 28451790 Free PMC article. Clinical Trial.
The Anatomical Location Shapes the Immune Infiltrate in Tumors of Same Etiology and Affects Survival.
Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, Duurland CL, van Unen V, Höllt T, van der Velden LA, van Egmond SL, Kortekaas KE, de Vos van Steenwijk PJ, van Poelgeest MIE, Welters MJP, van der Burg SH. Santegoets SJ, et al. Among authors: ehsan i. Clin Cancer Res. 2019 Jan 1;25(1):240-252. doi: 10.1158/1078-0432.CCR-18-1749. Epub 2018 Sep 17. Clin Cancer Res. 2019. PMID: 30224343
NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines.
van Montfoort N, Borst L, Korrer MJ, Sluijter M, Marijt KA, Santegoets SJ, van Ham VJ, Ehsan I, Charoentong P, André P, Wagtmann N, Welters MJP, Kim YJ, Piersma SJ, van der Burg SH, van Hall T. van Montfoort N, et al. Among authors: ehsan i. Cell. 2018 Dec 13;175(7):1744-1755.e15. doi: 10.1016/j.cell.2018.10.028. Epub 2018 Nov 29. Cell. 2018. PMID: 30503208 Free PMC article.
19 results