Ehlers MR - Search Results

1

Novel Therapeutic Approaches Targeting the Renin-Angiotensin System and Associated Peptides in Hypertension and Heart Failure.

Arendse LB, Danser AHJ, Poglitsch M, Touyz RM, Burnett JC Jr, Llorens-Cortes C, Ehlers MR, Sturrock ED. Arendse LB, et al. Among authors: ehlers mr. Pharmacol Rev. 2019 Oct;71(4):539-570. doi: 10.1124/pr.118.017129. Pharmacol Rev. 2019. PMID: 31537750 Free PMC article. Review.

2

Antifibrotic peptide N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP): opportunities for angiotensin-converting enzyme inhibitor design.

Douglas RG, Ehlers MR, Sturrock ED. Douglas RG, et al. Among authors: ehlers mr. Clin Exp Pharmacol Physiol. 2013 Aug;40(8):535-41. doi: 10.1111/1440-1681.12062. Clin Exp Pharmacol Physiol. 2013. PMID: 23351021 Review.

3

C domain-selective inhibition of angiotensin-converting enzyme.

Ehlers MR, Abrie JA, Sturrock ED. Ehlers MR, et al. J Renin Angiotensin Aldosterone Syst. 2013 Jun;14(2):189-92. doi: 10.1177/1470320313489206. J Renin Angiotensin Aldosterone Syst. 2013. PMID: 23686914 Free article. No abstract available.

4

Shedding the load of hypertension: the proteolytic processing of angiotensin-converting enzyme.

Ehlers MR, Gordon K, Schwager SL, Sturrock ED. Ehlers MR, et al. S Afr Med J. 2012 Mar 2;102(6):461-4. doi: 10.7196/samj.5596. S Afr Med J. 2012. PMID: 22668937 Review.

5

Ace revisited: a new target for structure-based drug design.

Acharya KR, Sturrock ED, Riordan JF, Ehlers MR. Acharya KR, et al. Among authors: ehlers mr. Nat Rev Drug Discov. 2003 Nov;2(11):891-902. doi: 10.1038/nrd1227. Nat Rev Drug Discov. 2003. PMID: 14668810 Free PMC article. Review.

6

Defining the boundaries of the testis angiotensin I-converting enzyme ectodomain.

Chubb AJ, Schwager SL, Woodman ZL, Ehlers MR, Sturrock ED. Chubb AJ, et al. Among authors: ehlers mr. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1225-30. doi: 10.1016/s0006-291x(02)02324-0. Biochem Biophys Res Commun. 2002. PMID: 12372418

7

Deletion of the cytoplasmic domain increases basal shedding of angiotensin-converting enzyme.

Chubb AJ, Schwager SL, van der Merwe E, Ehlers MR, Sturrock ED. Chubb AJ, et al. Among authors: ehlers mr. Biochem Biophys Res Commun. 2004 Feb 20;314(4):971-5. doi: 10.1016/j.bbrc.2003.12.198. Biochem Biophys Res Commun. 2004. PMID: 14751227

8

The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity.

Woodman ZL, Schwager SL, Redelinghuys P, Carmona AK, Ehlers MR, Sturrock ED. Woodman ZL, et al. Among authors: ehlers mr. Biochem J. 2005 Aug 1;389(Pt 3):739-44. doi: 10.1042/BJ20050187. Biochem J. 2005. PMID: 15813703 Free PMC article.

9

Deglycosylation, processing and crystallization of human testis angiotensin-converting enzyme.

Gordon K, Redelinghuys P, Schwager SL, Ehlers MR, Papageorgiou AC, Natesh R, Acharya KR, Sturrock ED. Gordon K, et al. Among authors: ehlers mr. Biochem J. 2003 Apr 15;371(Pt 2):437-42. doi: 10.1042/BJ20021842. Biochem J. 2003. PMID: 12542396 Free PMC article.

10

Homologous substitution of ACE C-domain regions with N-domain sequences: effect on processing, shedding, and catalytic properties.

Woodman ZL, Schwager SL, Redelinghuys P, Chubb AJ, van der Merwe EL, Ehlers MR, Sturrock ED. Woodman ZL, et al. Among authors: ehlers mr. Biol Chem. 2006 Aug;387(8):1043-51. doi: 10.1515/BC.2006.129. Biol Chem. 2006. PMID: 16895474

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