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RYR2 Channel Inhibition Is the Principal Mechanism of Flecainide Action in CPVT.
Circ Res. 2021 Feb 5;128(3):321-331. doi: 10.1161/CIRCRESAHA.120.316819. Epub 2020 Dec 10.
Circ Res. 2021.
PMID: 33297863
Free PMC article.
High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1.
Kozek KA, Glazer AM, Ng CA, Blackwell D, Egly CL, Vanags LR, Blair M, Mitchell D, Matreyek KA, Fowler DM, Knollmann BC, Vandenberg JI, Roden DM, Kroncke BM.
Kozek KA, et al. Among authors: egly cl.
Heart Rhythm. 2020 Dec;17(12):2180-2189. doi: 10.1016/j.hrthm.2020.05.041. Epub 2020 Jun 6.
Heart Rhythm. 2020.
PMID: 32522694
Free PMC article.
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Estimating the Posttest Probability of Long QT Syndrome Diagnosis for Rare KCNH2 Variants.
Kozek K, Wada Y, Sala L, Denjoy I, Egly C, O'Neill MJ, Aiba T, Shimizu W, Makita N, Ishikawa T, Crotti L, Spazzolini C, Kotta MC, Dagradi F, Castelletti S, Pedrazzini M, Gnecchi M, Leenhardt A, Salem JE, Ohno S, Zuo Y, Glazer AM, Mosley JD, Roden DM, Knollmann BC, Blume JD, Extramiana F, Schwartz PJ, Horie M, Kroncke BM.
Kozek K, et al.
Circ Genom Precis Med. 2021 Aug;14(4):e003289. doi: 10.1161/CIRCGEN.120.003289. Epub 2021 Jul 26.
Circ Genom Precis Med. 2021.
PMID: 34309407
Free PMC article.
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A High-Throughput Screening Assay to Identify Drugs that Can Treat Long QT Syndrome Caused by Trafficking-Deficient KV11.1 (hERG) Variants.
Egly CL, Blackwell DJ, Schmeckpeper J, Delisle BP, Weaver CD, Knollmann BC.
Egly CL, et al.
Mol Pharmacol. 2022 Apr;101(4):236-245. doi: 10.1124/molpharm.121.000421. Epub 2022 Feb 6.
Mol Pharmacol. 2022.
PMID: 35125346
Free PMC article.
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Eicosanoid-Regulated Myeloid ENaC and Isolevuglandin Formation in Human Salt-Sensitive Hypertension.
Ertuglu LA, Pitzer Mutchler A, Jamison S, Laffer CL, Elijovich F, Saleem M, Blackwell DJ, Kryshtal DO, Egly CL, Sahinoz M, Sheng Q, Wanjalla CN, Pakala S, Yu J, Gutierrez OM, Kleyman TR, Knollmann BC, Ikizler TA, Kirabo A.
Ertuglu LA, et al. Among authors: egly cl.
Hypertension. 2024 Mar;81(3):516-529. doi: 10.1161/HYPERTENSIONAHA.123.21285. Epub 2023 Sep 7.
Hypertension. 2024.
PMID: 37675576
Free article.
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Progesterone Metabolites Inhibit the Human Ether-a-go-go-Related Gene and Predict QT Interval Length.
Shugg T, Egly C, Stamatkin CW, Patil AS, Tisdale JE, Overholser BR.
Shugg T, et al.
J Clin Pharmacol. 2020 May;60(5):648-659. doi: 10.1002/jcph.1563. Epub 2019 Dec 12.
J Clin Pharmacol. 2020.
PMID: 31829451
Free PMC article.
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The proteostasis interactomes of trafficking-deficient K V 11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue.
Egly CL, Barny L, Do T, McDonald EF, Plate L, Knollmann BC.
Egly CL, et al.
bioRxiv [Preprint]. 2024 Jan 31:2024.01.31.574410. doi: 10.1101/2024.01.31.574410.
bioRxiv. 2024.
PMID: 38352392
Free PMC article.
Preprint.
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