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Roux-en-Y gastric bypass induces hepatic transcriptomic signatures and plasma metabolite changes indicative of improved cholesterol homeostasis.
Lalloyer F, Mogilenko DA, Verrijken A, Haas JT, Lamazière A, Kouach M, Descat A, Caron S, Vallez E, Derudas B, Gheeraert C, Baugé E, Despres G, Dirinck E, Tailleux A, Dombrowicz D, Van Gaal L, Eeckhoute J, Lefebvre P, Goossens JF, Francque S, Staels B. Lalloyer F, et al. Among authors: eeckhoute j. J Hepatol. 2023 Oct;79(4):898-909. doi: 10.1016/j.jhep.2023.05.012. Epub 2023 May 23. J Hepatol. 2023. PMID: 37230231
Mutations in hepatocyte nuclear factor 4alpha (HNF4alpha) gene associated with diabetes result in greater loss of HNF4alpha function in pancreatic beta-cells than in nonpancreatic beta-cells and in reduced activation of the apolipoprotein CIII promoter in hepatic cells.
Oxombre B, Moerman E, Eeckhoute J, Formstecher P, Laine B. Oxombre B, et al. Among authors: eeckhoute j. J Mol Med (Berl). 2002 Jul;80(7):423-30. doi: 10.1007/s00109-002-0340-8. Epub 2002 May 8. J Mol Med (Berl). 2002. PMID: 12110948
Targeting NF-kappaB in Waldenstrom macroglobulinemia.
Leleu X, Eeckhoute J, Jia X, Roccaro AM, Moreau AS, Farag M, Sacco A, Ngo HT, Runnels J, Melhem MR, Burwick N, Azab A, Azab F, Hunter Z, Hatjiharissi E, Carrasco DR, Treon SP, Witzig TE, Hideshima T, Brown M, Anderson KC, Ghobrial IM. Leleu X, et al. Among authors: eeckhoute j. Blood. 2008 May 15;111(10):5068-77. doi: 10.1182/blood-2007-09-115170. Epub 2008 Mar 11. Blood. 2008. PMID: 18334673 Free PMC article.
Unique ERalpha cistromes control cell type-specific gene regulation.
Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M. Krum SA, et al. Among authors: eeckhoute j. Mol Endocrinol. 2008 Nov;22(11):2393-406. doi: 10.1210/me.2008-0100. Epub 2008 Sep 25. Mol Endocrinol. 2008. PMID: 18818283 Free PMC article.
76 results