Edwards JP - Search Results

1

N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.

Cisar JS, Pietsch C, DeRatt LG, Jacoby E, Kazmi F, Keohane C, Legenski K, Matico R, Shaffer P, Simonnet Y, Tanner A, Wang CY, Wang W, Attar R, Edwards JP, Kuduk SD. Cisar JS, et al. Among authors: edwards jp. J Med Chem. 2022 Aug 25;65(16):11241-11256. doi: 10.1021/acs.jmedchem.2c00788. Epub 2022 Aug 4. J Med Chem. 2022. PMID: 35925768

2

Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.

Thurmond RL, Beavers MP, Cai H, Meduna SP, Gustin DJ, Sun S, Almond HJ, Karlsson L, Edwards JP. Thurmond RL, et al. Among authors: edwards jp. J Med Chem. 2004 Sep 23;47(20):4799-801. doi: 10.1021/jm0496133. J Med Chem. 2004. PMID: 15369380

3

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Grice CA, Tays KL, Savall BM, Wei J, Butler CR, Axe FU, Bembenek SD, Fourie AM, Dunford PJ, Lundeen K, Coles F, Xue X, Riley JP, Williams KN, Karlsson L, Edwards JP. Grice CA, et al. Among authors: edwards jp. J Med Chem. 2008 Jul 24;51(14):4150-69. doi: 10.1021/jm701575k. Epub 2008 Jun 28. J Med Chem. 2008. PMID: 18588282

4

Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements.

Ameriks MK, Axe FU, Bembenek SD, Edwards JP, Gu Y, Karlsson L, Randal M, Sun S, Thurmond RL, Zhu J. Ameriks MK, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6131-4. doi: 10.1016/j.bmcl.2009.09.014. Epub 2009 Sep 10. Bioorg Med Chem Lett. 2009. PMID: 19773165

5

Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.

Wiener JJ, Wickboldt AT, Nguyen S, Sun S, Rynberg R, Rizzolio M, Karlsson L, Edwards JP, Grice CA. Wiener JJ, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2013 Feb 15;23(4):1070-4. doi: 10.1016/j.bmcl.2012.12.014. Epub 2012 Dec 21. Bioorg Med Chem Lett. 2013. PMID: 23313244

6

Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists.

Savall BM, Chavez F, Tays K, Dunford PJ, Cowden JM, Hack MD, Wolin RL, Thurmond RL, Edwards JP. Savall BM, et al. Among authors: edwards jp. J Med Chem. 2014 Mar 27;57(6):2429-39. doi: 10.1021/jm401727m. Epub 2014 Feb 21. J Med Chem. 2014. PMID: 24495018

7

A Prospective Virtual Screening Study: Enriching Hit Rates and Designing Focus Libraries To Find Inhibitors of PI3Kδ and PI3Kγ.

Damm-Ganamet KL, Bembenek SD, Venable JW, Castro GG, Mangelschots L, Peeters DC, Mcallister HM, Edwards JP, Disepio D, Mirzadegan T. Damm-Ganamet KL, et al. Among authors: edwards jp. J Med Chem. 2016 May 12;59(9):4302-13. doi: 10.1021/acs.jmedchem.5b01974. Epub 2016 Apr 28. J Med Chem. 2016. PMID: 27043133

8

Identification and structure activity relationships of quinoline tertiary alcohol modulators of RORγt.

Kummer DA, Cummings MD, Abad M, Barbay J, Castro G, Wolin R, Kreutter KD, Maharoof U, Milligan C, Nishimura R, Pierce J, Schalk-Hihi C, Spurlino J, Urbanski M, Venkatesan H, Wang A, Woods C, Xue X, Edwards JP, Fourie AM, Leonard K. Kummer DA, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2017 May 1;27(9):2047-2057. doi: 10.1016/j.bmcl.2017.02.044. Epub 2017 Feb 21. Bioorg Med Chem Lett. 2017. PMID: 28318945

9

Identification and biological evaluation of thiazole-based inverse agonists of RORγt.

Gege C, Cummings MD, Albers M, Kinzel O, Kleymann G, Schlüter T, Steeneck C, Nelen MI, Milligan C, Spurlino J, Xue X, Leonard K, Edwards JP, Fourie A, Goldberg SD, Hoffmann T. Gege C, et al. Among authors: edwards jp. Bioorg Med Chem Lett. 2018 May 15;28(9):1446-1455. doi: 10.1016/j.bmcl.2018.03.093. Epub 2018 Apr 3. Bioorg Med Chem Lett. 2018. PMID: 29631962

10

Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors.

Jia H, Dai G, Su W, Xiao K, Weng J, Zhang Z, Wang Q, Yuan T, Shi F, Zhang Z, Chen W, Sai Y, Wang J, Li X, Cai Y, Yu J, Ren P, Venable J, Rao T, Edwards JP, Bembenek SD. Jia H, et al. Among authors: edwards jp. J Med Chem. 2019 May 23;62(10):4936-4948. doi: 10.1021/acs.jmedchem.8b02014. Epub 2019 May 8. J Med Chem. 2019. PMID: 31033293

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