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p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.
Lewis K, La Selva R, Maldonado E, Annis MG, Najyb O, Cepeda Cañedo E, Totten S, Hébert S, Sabourin V, Mirabelli C, Ciccolini E, Lehuédé C, Choinière L, Russo M, Avizonis D, Park M, St-Pierre J, Kleinman CL, Siegel PM, Ursini-Siegel J. Lewis K, et al. Among authors: cepeda canedo e. Redox Biol. 2024 Apr;70:103028. doi: 10.1016/j.redox.2024.103028. Epub 2024 Jan 5. Redox Biol. 2024. PMID: 38211442 Free PMC article.
3D chromatin remodeling potentiates transcriptional programs driving cell invasion.
Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, Catterall R, McCaffrey L, Deblois G, Kleinman C, Park M, Basik M, Witcher M. Lebeau B, et al. Among authors: canedo ec. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2203452119. doi: 10.1073/pnas.2203452119. Epub 2022 Aug 29. Proc Natl Acad Sci U S A. 2022. PMID: 36037342 Free PMC article.
STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer.
Totten SP, Im YK, Cepeda Cañedo E, Najyb O, Nguyen A, Hébert S, Ahn R, Lewis K, Lebeau B, La Selva R, Sabourin V, Martínez C, Savage P, Kuasne H, Avizonis D, Santos Martínez N, Chabot C, Aguilar-Mahecha A, Goulet ML, Dankner M, Witcher M, Petrecca K, Basik M, Pollak M, Topisirovic I, Lin R, Siegel PM, Kleinman CL, Park M, St-Pierre J, Ursini-Siegel J. Totten SP, et al. Among authors: cepeda canedo e. Nat Commun. 2021 Jun 3;12(1):3299. doi: 10.1038/s41467-021-23396-2. Nat Commun. 2021. PMID: 34083537 Free PMC article.
p66ShcA functions as a contextual promoter of breast cancer metastasis.
Lewis K, Kiepas A, Hudson J, Senecal J, Ha JR, Voorand E, Annis MG, Sabourin V, Ahn R, La Selva R, Tabariès S, Hsu BE, Siegel MJ, Dankner M, Canedo EC, Lajoie M, Watson IR, Brown CM, Siegel PM, Ursini-Siegel J. Lewis K, et al. Among authors: canedo ec. Breast Cancer Res. 2020 Jan 15;22(1):7. doi: 10.1186/s13058-020-1245-6. Breast Cancer Res. 2020. PMID: 31941526 Free PMC article.