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3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
Xue L, Shi DH, Harjani JR, Huang F, Beveridge JG, Dingjan T, Ban K, Diab S, Duffy S, Lucantoni L, Fletcher S, Chiu FCK, Blundell S, Ellis K, Ralph SA, Wirjanata G, Teguh S, Noviyanti R, Chavchich M, Creek D, Price RN, Marfurt J, Charman SA, Cuellar ME, Strasser JM, Dahlin JL, Walters MA, Edstein MD, Avery VM, Baell JB. Xue L, et al. Among authors: edstein md. J Med Chem. 2019 Mar 14;62(5):2485-2498. doi: 10.1021/acs.jmedchem.8b01799. Epub 2019 Mar 5. J Med Chem. 2019. PMID: 30715882
Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia.
Ratcliff A, Siswantoro H, Kenangalem E, Wuwung M, Brockman A, Edstein MD, Laihad F, Ebsworth EP, Anstey NM, Tjitra E, Price RN. Ratcliff A, et al. Among authors: edstein md. Trans R Soc Trop Med Hyg. 2007 Apr;101(4):351-9. doi: 10.1016/j.trstmh.2006.06.008. Epub 2006 Oct 9. Trans R Soc Trop Med Hyg. 2007. PMID: 17028048 Free PMC article. Clinical Trial.
Plasmodium vivax trophozoites insensitive to chloroquine.
Sharrock WW, Suwanarusk R, Lek-Uthai U, Edstein MD, Kosaisavee V, Travers T, Jaidee A, Sriprawat K, Price RN, Nosten F, Russell B. Sharrock WW, et al. Among authors: edstein md. Malar J. 2008 May 27;7:94. doi: 10.1186/1475-2875-7-94. Malar J. 2008. PMID: 18505560 Free PMC article.
Pharmacokinetics and ex vivo pharmacodynamic antimalarial activity of dihydroartemisinin-piperaquine in patients with uncomplicated falciparum malaria in Vietnam.
Nguyen DV, Nguyen QP, Nguyen ND, Le TT, Nguyen TD, Dinh DN, Nguyen TX, Bui D, Chavchich M, Edstein MD. Nguyen DV, et al. Among authors: edstein md. Antimicrob Agents Chemother. 2009 Aug;53(8):3534-7. doi: 10.1128/AAC.01717-08. Epub 2009 Jun 15. Antimicrob Agents Chemother. 2009. PMID: 19528277 Free PMC article. Clinical Trial.
151 results