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PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.
Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL. Kim SM, et al. Among authors: edinger al. Cancer Discov. 2018 Jul;8(7):866-883. doi: 10.1158/2159-8290.CD-17-1215. Epub 2018 Mar 23. Cancer Discov. 2018. PMID: 29572236 Free PMC article.
Cancer therapy: staying current with AMPK.
Fruman DA, Edinger AL. Fruman DA, et al. Among authors: edinger al. Biochem J. 2008 Jun 1;412(2):e3-5. doi: 10.1042/BJ20080823. Biochem J. 2008. PMID: 18466113
Nutrient transporters: the Achilles' heel of anabolism.
McCracken AN, Edinger AL. McCracken AN, et al. Among authors: edinger al. Trends Endocrinol Metab. 2013 Apr;24(4):200-8. doi: 10.1016/j.tem.2013.01.002. Epub 2013 Feb 8. Trends Endocrinol Metab. 2013. PMID: 23402769 Free PMC article. Review.
Loss of TSC2 confers resistance to ceramide and nutrient deprivation.
Guenther GG, Liu G, Ramirez MU, McMonigle RJ, Kim SM, McCracken AN, Joo Y, Ushach I, Nguyen NL, Edinger AL. Guenther GG, et al. Among authors: edinger al. Oncogene. 2014 Apr 3;33(14):1776-87. doi: 10.1038/onc.2013.139. Epub 2013 Apr 22. Oncogene. 2014. PMID: 23604129 Free PMC article.
Attacking the supply wagons to starve cancer cells to death.
Selwan EM, Finicle BT, Kim SM, Edinger AL. Selwan EM, et al. Among authors: edinger al. FEBS Lett. 2016 Apr;590(7):885-907. doi: 10.1002/1873-3468.12121. Epub 2016 Mar 22. FEBS Lett. 2016. PMID: 26938658 Free PMC article. Review.
Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.
Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S. Perryman MS, et al. Among authors: edinger al. Bioorg Med Chem. 2016 Sep 15;24(18):4390-4397. doi: 10.1016/j.bmc.2016.07.038. Epub 2016 Jul 18. Bioorg Med Chem. 2016. PMID: 27475534
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL. Kim SM, et al. Among authors: edinger al. J Clin Invest. 2016 Nov 1;126(11):4088-4102. doi: 10.1172/JCI87148. Epub 2016 Sep 26. J Clin Invest. 2016. PMID: 27669461 Free PMC article.
Nutrient scavenging in cancer.
Finicle BT, Jayashankar V, Edinger AL. Finicle BT, et al. Among authors: edinger al. Nat Rev Cancer. 2018 Oct;18(10):619-633. doi: 10.1038/s41568-018-0048-x. Nat Rev Cancer. 2018. PMID: 30097614 Review.
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