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1952 2
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1988 3
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1994 2
1995 3
1996 6
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1998 24
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2003 49
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2007 15
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843 results

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Page 1
Life on the edg.
Lynch KR, Im DS. Lynch KR, et al. Trends Pharmacol Sci. 1999 Dec;20(12):473-5. doi: 10.1016/s0165-6147(99)01401-7. Trends Pharmacol Sci. 1999. PMID: 10603487 Review. No abstract available.
Non-Edg family lysophosphatidic acid (LPA) receptors.
Ishii S, Noguchi K, Yanagida K. Ishii S, et al. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. doi: 10.1016/j.prostaglandins.2009.06.001. Epub 2009 Jun 12. Prostaglandins Other Lipid Mediat. 2009. PMID: 19524700 Review.
They share 50-57% amino acid identities and, together with five sphingosine-1-phosphate receptors (S1P(1)/Edg1, S1P(2)/Edg5, S1P(3)/Edg3, S1P(4)/Edg6, and S1P(5)/Edg8), comprise the endothelial cell differentiation gene (Edg) family. However, even after finding of the E …
They share 50-57% amino acid identities and, together with five sphingosine-1-phosphate receptors (S1P(1)/Edg1, S1P(2)/Edg5, S1P(3)/Edg3, S1 …
Non-Edg family LPA receptors: the cutting edge of LPA research.
Yanagida K, Ishii S. Yanagida K, et al. J Biochem. 2011 Sep;150(3):223-32. doi: 10.1093/jb/mvr087. Epub 2011 Jul 11. J Biochem. 2011. PMID: 21746769 Review.
The discovery of this receptor, which is structurally distinct from the Edg family LPA receptors, led to the identification of two additional LPA receptors, LPA5 and LPA6, homologous to LPA4. These 'non-Edg family' LPA receptors now provide a new framework for under …
The discovery of this receptor, which is structurally distinct from the Edg family LPA receptors, led to the identification of two ad …
Current progress in non-Edg family LPA receptor research.
Yanagida K, Kurikawa Y, Shimizu T, Ishii S. Yanagida K, et al. Biochim Biophys Acta. 2013 Jan;1831(1):33-41. doi: 10.1016/j.bbalip.2012.08.003. Epub 2012 Aug 11. Biochim Biophys Acta. 2013. PMID: 22902318 Review.
Until 2003, the functions of LPA were thought to be elicited exclusively by three subtypes of the endothelial differentiation gene (Edg) family of G protein-coupled receptors - LPA(1), LPA(2), and LPA(3). ...Here we review recent progress in the non-Edg family LPA r …
Until 2003, the functions of LPA were thought to be elicited exclusively by three subtypes of the endothelial differentiation gene (Edg …
Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells.
Kohno T, Igarashi Y. Kohno T, et al. Glycoconj J. 2004;21(8-9):497-501. doi: 10.1007/s10719-004-5540-8. Glycoconj J. 2004. PMID: 15750791 Review.
Sphingosine 1-phosphate (Sph-1-P) is a bioactive lipid mediator released from activated platelets. To date, 5 seven-transmembrane-spanning receptors, Edg-1/S1P1, Edg-3/S1P3, Edg-5/S1P2, Edg-6/S1P4 and Edg-8/S1P5, have been identified as specific …
Sphingosine 1-phosphate (Sph-1-P) is a bioactive lipid mediator released from activated platelets. To date, 5 seven-transmembrane-spanning r …
Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors.
Hla T, Lee MJ, Ancellin N, Thangada S, Liu CH, Kluk M, Chae SS, Wu MT. Hla T, et al. Ann N Y Acad Sci. 2000 Apr;905:16-24. doi: 10.1111/j.1749-6632.2000.tb06534.x. Ann N Y Acad Sci. 2000. PMID: 10818438 Review.
Three other GPCRs, trivially termed EDG-3, EDG-5, and EDG-8, are also high-affinity receptors for SPP. The four SPP receptor subtypes regulate different intracellular signal transduction pathways. In vascular endothelial cells, cooperative signaling between …
Three other GPCRs, trivially termed EDG-3, EDG-5, and EDG-8, are also high-affinity receptors for SPP. The four SPP rec …
Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors.
Van Brocklyn JR, Behbahani B, Lee NH. Van Brocklyn JR, et al. Biochim Biophys Acta. 2002 May 23;1582(1-3):89-93. doi: 10.1016/s1388-1981(02)00141-5. Biochim Biophys Acta. 2002. PMID: 12069814 Review.
Sphingosine-1-phosphate (S1P) binds to and signals through several members of a group of G protein-coupled receptors (GPCRs) known as the S1P/EDG family. Several of these receptors are coexpressed in various cell types and recent reports have shown that biological effects …
Sphingosine-1-phosphate (S1P) binds to and signals through several members of a group of G protein-coupled receptors (GPCRs) known as the S1 …
The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities.
Takuwa Y, Takuwa N, Sugimoto N. Takuwa Y, et al. J Biochem. 2002 Jun;131(6):767-71. doi: 10.1093/oxfordjournals.jbchem.a003163. J Biochem. 2002. PMID: 12038970 Free article. Review.
Indeed, recent investigation has revealed that S1P and LPA act via a single family of G protein-coupled receptors designated as Edg. Thus, the Edg isoforms, Edg1 (also called S1P(1)), Edg5 (S1P(2)), Edg3 (S1P(3)), Edg6 (S1P(4)), and Edg8 (S1P(5)), are specific recep …
Indeed, recent investigation has revealed that S1P and LPA act via a single family of G protein-coupled receptors designated as Edg. …
EDG receptors and hepatic pathophysiology of LPA and S1P: EDG-ology of liver injury.
Svetlov SI, Sautin YY, Crawford JM. Svetlov SI, et al. Biochim Biophys Acta. 2002 May 23;1582(1-3):251-6. doi: 10.1016/s1388-1981(02)00178-6. Biochim Biophys Acta. 2002. PMID: 12069835 Review.
The cellular effects of LPA and S1P are mediated predominantly via endothelial differentiation gene (EDG) receptors. Yet, the biological significance of LPA, S1P and their EDG receptors in cells of the liver remains unclear. ...LPA, and possibly S1P, appear to be es …
The cellular effects of LPA and S1P are mediated predominantly via endothelial differentiation gene (EDG) receptors. Yet, the biologi …
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors.
Kluk MJ, Hla T. Kluk MJ, et al. Biochim Biophys Acta. 2002 May 23;1582(1-3):72-80. doi: 10.1016/s1388-1981(02)00139-7. Biochim Biophys Acta. 2002. PMID: 12069812 Review.
The sphingosine-1-phosphate/Endothelial Differentiation Gene (S1P/EDG) family of G-protein-coupled receptors (GPCR) currently includes five different isoforms, which differentially regulate fundamental cellular processes such as migration, proliferation, cytoskeletal organ …
The sphingosine-1-phosphate/Endothelial Differentiation Gene (S1P/EDG) family of G-protein-coupled receptors (GPCR) currently include …
843 results