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Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, Q Do K, Halliez S, Bezzi P, Buée L, Leuba G, Colin M, Toni N, Déglon N. Richetin K, et al. Among authors: eddarkaoui s. Nat Neurosci. 2020 Dec;23(12):1567-1579. doi: 10.1038/s41593-020-00728-x. Epub 2020 Nov 9. Nat Neurosci. 2020. PMID: 33169029
Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.
Danis C, Dupré E, Zejneli O, Caillierez R, Arrial A, Bégard S, Mortelecque J, Eddarkaoui S, Loyens A, Cantrelle FX, Hanoulle X, Rain JC, Colin M, Buée L, Landrieu I. Danis C, et al. Among authors: eddarkaoui s. Mol Ther. 2022 Apr 6;30(4):1484-1499. doi: 10.1016/j.ymthe.2022.01.009. Epub 2022 Jan 7. Mol Ther. 2022. PMID: 35007758 Free PMC article.
Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model.
Leboucher A, Ahmed T, Caron E, Tailleux A, Raison S, Joly-Amado A, Marciniak E, Carvalho K, Hamdane M, Bantubungi K, Lancel S, Eddarkaoui S, Caillierez R, Vallez E, Staels B, Vieau D, Balschun D, Buee L, Blum D. Leboucher A, et al. Among authors: eddarkaoui s. Neurobiol Dis. 2019 May;125:14-22. doi: 10.1016/j.nbd.2019.01.008. Epub 2019 Jan 19. Neurobiol Dis. 2019. PMID: 30665005
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P. Sergeant N, et al. Among authors: eddarkaoui s. Neurobiol Dis. 2019 Sep;129:217-233. doi: 10.1016/j.nbd.2019.03.028. Epub 2019 Mar 27. Neurobiol Dis. 2019. PMID: 30928644
Encephalopathy induced by Alzheimer brain inoculation in a non-human primate.
Gary C, Lam S, Hérard AS, Koch JE, Petit F, Gipchtein P, Sawiak SJ, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys JP; French Neuropathology Network; Brouillet E, Buée L, Comoy EE, Pifferi F, Picq JL, Dhenain M. Gary C, et al. Among authors: eddarkaoui s. Acta Neuropathol Commun. 2019 Sep 4;7(1):126. doi: 10.1186/s40478-019-0771-x. Acta Neuropathol Commun. 2019. PMID: 31481130 Free PMC article.
Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.
Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D. Faivre E, et al. Among authors: eddarkaoui s. Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30050407 Free PMC article.
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Leboucher A, Laurent C, Fernandez-Gomez FJ, Burnouf S, Troquier L, Eddarkaoui S, Demeyer D, Caillierez R, Zommer N, Vallez E, Bantubungi K, Breton C, Pigny P, Buée-Scherrer V, Staels B, Hamdane M, Tailleux A, Buée L, Blum D. Leboucher A, et al. Among authors: eddarkaoui s. Diabetes. 2013 May;62(5):1681-8. doi: 10.2337/db12-0866. Epub 2012 Dec 18. Diabetes. 2013. PMID: 23250356 Free PMC article.
NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Burnouf S, Martire A, Derisbourg M, Laurent C, Belarbi K, Leboucher A, Fernandez-Gomez FJ, Troquier L, Eddarkaoui S, Grosjean ME, Demeyer D, Muhr-Tailleux A, Buisson A, Sergeant N, Hamdane M, Humez S, Popoli P, Buée L, Blum D. Burnouf S, et al. Among authors: eddarkaoui s. Aging Cell. 2013 Feb;12(1):11-23. doi: 10.1111/acel.12018. Epub 2012 Nov 23. Aging Cell. 2013. PMID: 23082852 Free article.
35 results