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Could the Urease of the Gut Bacterium Proteus mirabilis Play a Role in the Altered Gut-Brain Talk Associated with Parkinson's Disease?
Grahl MVC, Andrade BDS, Perin APA, Neves GA, Duarte LS, Uberti AF, Hohl KS, Follmer C, Carlini CR. Grahl MVC, et al. Microorganisms. 2023 Aug 9;11(8):2042. doi: 10.3390/microorganisms11082042. Microorganisms. 2023. PMID: 37630602 Free PMC article.
The urease, but not the PmUrebeta, altered the morphology of alpha-synuclein aggregates in vitro, forming fragmented aggregates. We concluded that PMU promotes pro-inflammatory effects in cultured cells. In vivo, PMU induces neuroinflammation and a depressive-like phenotyp …
The urease, but not the PmUrebeta, altered the morphology of alpha-synuclein aggregates in vitro, forming fragmented aggregates. We conclude …
Proteus mirabilis Urease: Unsuspected Non-Enzymatic Properties Relevant to Pathogenicity.
Grahl MVC, Uberti AF, Broll V, Bacaicoa-Caruso P, Meirelles EF, Carlini CR. Grahl MVC, et al. Int J Mol Sci. 2021 Jul 4;22(13):7205. doi: 10.3390/ijms22137205. Int J Mol Sci. 2021. PMID: 34281258 Free PMC article.
We have shown that PMU, besides urinary stone formation, can potentially contribute in other ways to pathogenesis. Our data suggest that PMU triggers pro-inflammatory effects and may affect cells beyond the renal system, indicating a possible role in extra-urinary diseases …
We have shown that PMU, besides urinary stone formation, can potentially contribute in other ways to pathogenesis. Our data suggest that PMU …