Eckhard U - Search Results

1

Molecular and in vivo studies of a glutamate-class prolyl-endopeptidase for coeliac disease therapy.

Del Amo-Maestro L, Mendes SR, Rodríguez-Banqueri A, Garzon-Flores L, Girbal M, Rodríguez-Lagunas MJ, Guevara T, Franch À, Pérez-Cano FJ, Eckhard U, Gomis-Rüth FX. Del Amo-Maestro L, et al. Among authors: eckhard u. Nat Commun. 2022 Aug 1;13(1):4446. doi: 10.1038/s41467-022-32215-1. Nat Commun. 2022. PMID: 35915115 Free PMC article.

2

LysargiNase mirrors trypsin for protein C-terminal and methylation-site identification.

Huesgen PF, Lange PF, Rogers LD, Solis N, Eckhard U, Kleifeld O, Goulas T, Gomis-Rüth FX, Overall CM. Huesgen PF, et al. Among authors: eckhard u. Nat Methods. 2015 Jan;12(1):55-8. doi: 10.1038/nmeth.3177. Epub 2014 Nov 24. Nat Methods. 2015. PMID: 25419962 Free article.

3

The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin β by endogenous fetuin-B.

Eckhard U, Körschgen H, von Wiegen N, Stöcker W, Gomis-Rüth FX. Eckhard U, et al. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2023839118. doi: 10.1073/pnas.2023839118. Proc Natl Acad Sci U S A. 2021. PMID: 33782129 Free PMC article.

4

Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system.

Mizgalska D, Goulas T, Rodríguez-Banqueri A, Veillard F, Madej M, Małecka E, Szczesniak K, Ksiazek M, Widziołek M, Guevara T, Eckhard U, Solà M, Potempa J, Gomis-Rüth FX. Mizgalska D, et al. Among authors: eckhard u. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2103573118. doi: 10.1073/pnas.2103573118. Epub 2021 Sep 30. Proc Natl Acad Sci U S A. 2021. PMID: 34593635 Free PMC article.

5

An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin.

Mendes SR, Eckhard U, Rodríguez-Banqueri A, Guevara T, Czermak P, Marcos E, Vilcinskas A, Gomis-Rüth FX. Mendes SR, et al. Among authors: eckhard u. Comput Struct Biotechnol J. 2022 Jan 6;20:534-544. doi: 10.1016/j.csbj.2022.01.001. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35465156 Free PMC article.

6

Repositioning small molecule drugs as allosteric inhibitors of the BFT-3 toxin from enterotoxigenic Bacteroides fragilis.

Jimenez-Alesanco A, Eckhard U, Asencio Del Rio M, Vega S, Guevara T, Velazquez-Campoy A, Gomis-Rüth FX, Abian O. Jimenez-Alesanco A, et al. Among authors: eckhard u. Protein Sci. 2022 Oct;31(10):e4427. doi: 10.1002/pro.4427. Protein Sci. 2022. PMID: 36173175 Free PMC article.

7

De novo design of immunoglobulin-like domains.

Chidyausiku TM, Mendes SR, Klima JC, Nadal M, Eckhard U, Roel-Touris J, Houliston S, Guevara T, Haddox HK, Moyer A, Arrowsmith CH, Gomis-Rüth FX, Baker D, Marcos E. Chidyausiku TM, et al. Among authors: eckhard u. Nat Commun. 2022 Oct 3;13(1):5661. doi: 10.1038/s41467-022-33004-6. Nat Commun. 2022. PMID: 36192397 Free PMC article.

8

A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.

Książek M, Goulas T, Mizgalska D, Rodríguez-Banqueri A, Eckhard U, Veillard F, Waligórska I, Benedyk-Machaczka M, Sochaj-Gregorczyk AM, Madej M, Thøgersen IB, Enghild JJ, Cuppari A, Arolas JL, de Diego I, López-Pelegrín M, Garcia-Ferrer I, Guevara T, Dive V, Zani ML, Moreau T, Potempa J, Gomis-Rüth FX. Książek M, et al. Among authors: eckhard u. Chem Sci. 2022 Dec 12;14(4):869-888. doi: 10.1039/d2sc04166a. eCollection 2023 Jan 25. Chem Sci. 2022. PMID: 36755705 Free PMC article.

9

Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases.

Rodríguez-Banqueri A, Moliner-Culubret M, Mendes SR, Guevara T, Eckhard U, Gomis-Rüth FX. Rodríguez-Banqueri A, et al. Among authors: eckhard u. Dalton Trans. 2023 Mar 21;52(12):3610-3622. doi: 10.1039/d3dt00458a. Dalton Trans. 2023. PMID: 36857690

10

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella.

Eckhard U, Bandukwala H, Mansfield MJ, Marino G, Cheng J, Wallace I, Holyoak T, Charles TC, Austin J, Overall CM, Doxey AC. Eckhard U, et al. Nat Commun. 2017 Sep 12;8(1):521. doi: 10.1038/s41467-017-00599-0. Nat Commun. 2017. PMID: 28900095 Free PMC article.

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