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High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo.
Huayamares SG, Lokugamage MP, Rab R, Da Silva Sanchez AJ, Kim H, Radmand A, Loughrey D, Lian L, Hou Y, Achyut BR, Ehrhardt A, Hong JS, Sago CD, Paunovska K, Echeverri ES, Vanover D, Santangelo PJ, Sorscher EJ, Dahlman JE. Huayamares SG, et al. Among authors: echeverri es. J Control Release. 2023 May;357:394-403. doi: 10.1016/j.jconrel.2023.04.005. Epub 2023 Apr 12. J Control Release. 2023. PMID: 37028451 Free PMC article.
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver.
Sago CD, Lokugamage MP, Loughrey D, Lindsay KE, Hincapie R, Krupczak BR, Kalathoor S, Sato M, Echeverri ES, Fitzgerald JP, Gan Z, Gamboa L, Paunovska K, Sanhueza CA, Hatit MZC, Finn MG, Santangelo PJ, Dahlman JE. Sago CD, et al. Among authors: echeverri es. Nat Biomed Eng. 2022 Feb;6(2):157-167. doi: 10.1038/s41551-022-00847-9. Epub 2022 Feb 21. Nat Biomed Eng. 2022. PMID: 35190679
Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery.
Da Silva Sanchez AJ, Dobrowolski C, Cristian A, Echeverri ES, Zhao K, Hatit MZC, Loughrey D, Paunovska K, Dahlman JE. Da Silva Sanchez AJ, et al. Among authors: echeverri es. Nano Lett. 2022 Jun 22;22(12):4822-4830. doi: 10.1021/acs.nanolett.2c01133. Epub 2022 Jun 7. Nano Lett. 2022. PMID: 35671473
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure.
Paunovska K, Da Silva Sanchez AJ, Lokugamage MP, Loughrey D, Echeverri ES, Cristian A, Hatit MZC, Santangelo PJ, Zhao K, Dahlman JE. Paunovska K, et al. Among authors: echeverri es. Nano Lett. 2022 Dec 28;22(24):10025-10033. doi: 10.1021/acs.nanolett.2c03741. Epub 2022 Dec 15. Nano Lett. 2022. PMID: 36521071