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Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Lan T, Ganapathy US, Sharma S, Ahn YM, Zimmerman M, Molodtsov V, Hegde P, Gengenbacher M, Ebright RH, Dartois V, Freundlich JS, Dick T, Aldrich CC. Lan T, et al. Among authors: ebright rh. Angew Chem Int Ed Engl. 2022 Nov 7;61(45):e202211498. doi: 10.1002/anie.202211498. Epub 2022 Oct 12. Angew Chem Int Ed Engl. 2022. PMID: 36222275 Free PMC article.
Structural basis of transcription-translation coupling.
Wang C, Molodtsov V, Firlar E, Kaelber JT, Blaha G, Su M, Ebright RH. Wang C, et al. Among authors: ebright rh. Science. 2020 Sep 11;369(6509):1359-1365. doi: 10.1126/science.abb5317. Epub 2020 Aug 20. Science. 2020. PMID: 32820061 Free PMC article.
Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS. Ma Z, et al. Among authors: ebright rh. J Med Chem. 2022 Mar 24;65(6):4481-4495. doi: 10.1021/acs.jmedchem.1c02045. Epub 2022 Feb 17. J Med Chem. 2022. PMID: 35175750 Free PMC article.
Structural and mechanistic basis of σ-dependent transcriptional pausing.
Pukhrambam C, Molodtsov V, Kooshkbaghi M, Tareen A, Vu H, Skalenko KS, Su M, Yin Z, Winkelman JT, Kinney JB, Ebright RH, Nickels BE. Pukhrambam C, et al. Among authors: ebright rh. Proc Natl Acad Sci U S A. 2022 Jun 7;119(23):e2201301119. doi: 10.1073/pnas.2201301119. Epub 2022 Jun 2. Proc Natl Acad Sci U S A. 2022. PMID: 35653571 Free PMC article.
Structural basis of Rho-dependent transcription termination.
Molodtsov V, Wang C, Firlar E, Kaelber JT, Ebright RH. Molodtsov V, et al. Among authors: ebright rh. Nature. 2023 Feb;614(7947):367-374. doi: 10.1038/s41586-022-05658-1. Epub 2023 Jan 25. Nature. 2023. PMID: 36697824 Free PMC article.
188 results