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A ciprofloxacin derivative with four mechanisms of action overcomes paclitaxel resistance in p53-mutant and MDR1 gene-expressing type II human endometrial cancer.
Alhaj-Suliman SO, Naguib YW, Wafa EI, Saha S, Ebeid K, Meng X, Mohammed HH, Abuo-Rahma GEA, Yang S, Salem AK. Alhaj-Suliman SO, et al. Among authors: ebeid k. Biomaterials. 2023 May;296:122093. doi: 10.1016/j.biomaterials.2023.122093. Epub 2023 Mar 17. Biomaterials. 2023. PMID: 36965280 Free PMC article.
Synthetically lethal nanoparticles for treatment of endometrial cancer.
Ebeid K, Meng X, Thiel KW, Do AV, Geary SM, Morris AS, Pham EL, Wongrakpanich A, Chhonker YS, Murry DJ, Leslie KK, Salem AK. Ebeid K, et al. Nat Nanotechnol. 2018 Jan;13(1):72-81. doi: 10.1038/s41565-017-0009-7. Epub 2017 Dec 4. Nat Nanotechnol. 2018. PMID: 29203914 Free PMC article.
The MEK 1/2 inhibitor PD98059 exhibits synergistic anti-endometrial cancer activity with paclitaxel in vitro and enhanced tissue distribution in vivo when formulated into PAMAM-coated PLGA-PEG nanoparticles.
Wiwatchaitawee K, Mekkawy AI, Quarterman JC, Naguib YW, Ebeid K, Geary SM, Salem AK. Wiwatchaitawee K, et al. Among authors: ebeid k. Drug Deliv Transl Res. 2022 Jul;12(7):1684-1696. doi: 10.1007/s13346-021-01065-7. Epub 2021 Oct 11. Drug Deliv Transl Res. 2022. PMID: 34635984 Free PMC article.
New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.
Mohammed HHH, Abd El-Hafeez AA, Ebeid K, Mekkawy AI, Abourehab MAS, Wafa EI, Alhaj-Suliman SO, Salem AK, Ghosh P, Abuo-Rahma GEA, Hayallah AM, Abbas SH. Mohammed HHH, et al. Among authors: ebeid k. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1346-1363. doi: 10.1080/14756366.2022.2072308. J Enzyme Inhib Med Chem. 2022. PMID: 35548854 Free PMC article.
38 results