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Hydrogen peroxide signaling via its transformation to a stereospecific alkyl hydroperoxide that escapes reductive inactivation.
Queiroz RF, Stanley CP, Wolhuter K, Kong SMY, Rajivan R, McKinnon N, Nguyen GTH, Roveri A, Guttzeit S, Eaton P, Donald WA, Ursini F, Winterbourn CC, Ayer A, Stocker R. Queiroz RF, et al. Among authors: eaton p. Nat Commun. 2021 Nov 16;12(1):6626. doi: 10.1038/s41467-021-26991-5. Nat Commun. 2021. PMID: 34785665 Free PMC article.
Deficient angiogenesis in redox-dead Cys17Ser PKARIα knock-in mice.
Burgoyne JR, Rudyk O, Cho HJ, Prysyazhna O, Hathaway N, Weeks A, Evans R, Ng T, Schröder K, Brandes RP, Shah AM, Eaton P. Burgoyne JR, et al. Among authors: eaton p. Nat Commun. 2015 Aug 10;6:7920. doi: 10.1038/ncomms8920. Nat Commun. 2015. PMID: 26258640 Free article.
Disulfide-activated protein kinase G Iα regulates cardiac diastolic relaxation and fine-tunes the Frank-Starling response.
Scotcher J, Prysyazhna O, Boguslavskyi A, Kistamas K, Hadgraft N, Martin ED, Worthington J, Rudyk O, Rodriguez Cutillas P, Cuello F, Shattock MJ, Marber MS, Conte MR, Greenstein A, Greensmith DJ, Venetucci L, Timms JF, Eaton P. Scotcher J, et al. Among authors: eaton p. Nat Commun. 2016 Oct 26;7:13187. doi: 10.1038/ncomms13187. Nat Commun. 2016. PMID: 27782102 Free PMC article.
Singlet molecular oxygen regulates vascular tone and blood pressure in inflammation.
Stanley CP, Maghzal GJ, Ayer A, Talib J, Giltrap AM, Shengule S, Wolhuter K, Wang Y, Chadha P, Suarna C, Prysyazhna O, Scotcher J, Dunn LL, Prado FM, Nguyen N, Odiba JO, Baell JB, Stasch JP, Yamamoto Y, Di Mascio P, Eaton P, Payne RJ, Stocker R. Stanley CP, et al. Among authors: eaton p. Nature. 2019 Feb;566(7745):548-552. doi: 10.1038/s41586-019-0947-3. Epub 2019 Feb 13. Nature. 2019. PMID: 30760924
Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase".
Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR. Prysyazhna O, et al. Among authors: eaton p. Circulation. 2019 Nov 26;140(22):e810-e811. doi: 10.1161/CIRCULATIONAHA.119.043869. Epub 2019 Nov 25. Circulation. 2019. PMID: 31765257 No abstract available.
231 results