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Cysteine redox sensor in PKGIa enables oxidant-induced activation.
Burgoyne JR, Madhani M, Cuello F, Charles RL, Brennan JP, Schröder E, Browning DD, Eaton P. Burgoyne JR, et al. Among authors: eaton p. Science. 2007 Sep 7;317(5843):1393-7. doi: 10.1126/science.1144318. Epub 2007 Aug 23. Science. 2007. PMID: 17717153
Protein kinase G oxidation is a major cause of injury during sepsis.
Rudyk O, Phinikaridou A, Prysyazhna O, Burgoyne JR, Botnar RM, Eaton P. Rudyk O, et al. Among authors: eaton p. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9909-13. doi: 10.1073/pnas.1301026110. Epub 2013 May 28. Proc Natl Acad Sci U S A. 2013. PMID: 23716652 Free PMC article.
Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity.
Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V, Scotcher J, Dees C, Subramanian H, Butt E, Kamynina A, Schobesberger S, King SB, Nikolaev VO, de Wit C, Leichert LI, Feil R, Eaton P, Cuello F. Donzelli S, et al. Among authors: eaton p. Sci Rep. 2017 Aug 30;7(1):9938. doi: 10.1038/s41598-017-09275-1. Sci Rep. 2017. PMID: 28855531 Free PMC article.
PKG1α oxidation negatively regulates food seeking behaviour and reward.
Duraffourd C, Huckstepp RTR, Braren I, Fernandes C, Brock O, Delogu A, Prysyazhna O, Burgoyne J, Eaton P. Duraffourd C, et al. Among authors: eaton p. Redox Biol. 2019 Feb;21:101077. doi: 10.1016/j.redox.2018.101077. Epub 2018 Dec 18. Redox Biol. 2019. PMID: 30593979 Free PMC article.
231 results