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A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
Eastman RT, Pattaradilokrat S, Raj DK, Dixit S, Deng B, Miura K, Yuan J, Tanaka TQ, Johnson RL, Jiang H, Huang R, Williamson KC, Lambert LE, Long C, Austin CP, Wu Y, Su XZ. Eastman RT, et al. Antimicrob Agents Chemother. 2013 Jan;57(1):425-35. doi: 10.1128/AAC.00920-12. Epub 2012 Nov 5. Antimicrob Agents Chemother. 2013. PMID: 23129054 Free PMC article.
Ex vivo susceptibility of Plasmodium falciparum to antimalarial drugs in western, northern, and eastern Cambodia, 2011-2012: association with molecular markers.
Lim P, Dek D, Try V, Eastman RT, Chy S, Sreng S, Suon S, Mao S, Sopha C, Sam B, Ashley EA, Miotto O, Dondorp AM, White NJ, Su XZ, Char MC, Anderson JM, Amaratunga C, Menard D, Fairhurst RM. Lim P, et al. Among authors: eastman rt. Antimicrob Agents Chemother. 2013 Nov;57(11):5277-83. doi: 10.1128/AAC.00687-13. Epub 2013 Aug 12. Antimicrob Agents Chemother. 2013. PMID: 23939897 Free PMC article.
A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.
Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AM, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, Verlinde CL, Su XZ, Kappe SH, Maly DJ, Fan E, Van Voorhis WC. Ojo KK, et al. Among authors: eastman rt. J Infect Dis. 2014 Jan 15;209(2):275-84. doi: 10.1093/infdis/jit522. Epub 2013 Oct 10. J Infect Dis. 2014. PMID: 24123773 Free PMC article.
Plasmodium genetic loci linked to host cytokine and chemokine responses.
Pattaradilokrat S, Li J, Wu J, Qi Y, Eastman RT, Zilversmit M, Nair SC, Huaman MC, Quinones M, Jiang H, Li N, Zhu J, Zhao K, Kaneko O, Long CA, Su XZ. Pattaradilokrat S, et al. Among authors: eastman rt. Genes Immun. 2014 Apr-May;15(3):145-52. doi: 10.1038/gene.2013.74. Epub 2014 Jan 23. Genes Immun. 2014. PMID: 24452266 Free PMC article.
High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.
Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ. Mott BT, et al. Among authors: eastman rt. Sci Rep. 2015 Sep 25;5:13891. doi: 10.1038/srep13891. Sci Rep. 2015. PMID: 26403635 Free PMC article.
Actinoramide A Identified as a Potent Antimalarial from Titration-Based Screening of Marine Natural Product Extracts.
Cheng KC, Cao S, Raveh A, MacArthur R, Dranchak P, Chlipala G, Okoneski MT, Guha R, Eastman RT, Yuan J, Schultz PJ, Su XZ, Tamayo-Castillo G, Matainaho T, Clardy J, Sherman DH, Inglese J. Cheng KC, et al. Among authors: eastman rt. J Nat Prod. 2015 Oct 23;78(10):2411-22. doi: 10.1021/acs.jnatprod.5b00489. Epub 2015 Oct 14. J Nat Prod. 2015. PMID: 26465675 Free PMC article.
64 results