Ealick SE - Search Results

1

Structural biology of S-adenosylmethionine decarboxylase.

Bale S, Ealick SE. Bale S, et al. Among authors: ealick se. Amino Acids. 2010 Feb;38(2):451-60. doi: 10.1007/s00726-009-0404-y. Epub 2009 Dec 8. Amino Acids. 2010. PMID: 19997761 Free PMC article. Review.

2

Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase.

Bale S, Lopez MM, Makhatadze GI, Fang Q, Pegg AE, Ealick SE. Bale S, et al. Among authors: ealick se. Biochemistry. 2008 Dec 16;47(50):13404-17. doi: 10.1021/bi801732m. Biochemistry. 2008. PMID: 19053272 Free PMC article.

3

New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.

McCloskey DE, Bale S, Secrist JA 3rd, Tiwari A, Moss TH 3rd, Valiyaveettil J, Brooks WH, Guida WC, Pegg AE, Ealick SE. McCloskey DE, et al. Among authors: ealick se. J Med Chem. 2009 Mar 12;52(5):1388-407. doi: 10.1021/jm801126a. J Med Chem. 2009. PMID: 19209891 Free PMC article.

4

Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.

Bale S, Brooks W, Hanes JW, Mahesan AM, Guida WC, Ealick SE. Bale S, et al. Among authors: ealick se. Biochemistry. 2009 Jul 14;48(27):6423-30. doi: 10.1021/bi900590m. Biochemistry. 2009. PMID: 19527050 Free PMC article.

5

Complexes of Thermotoga maritimaS-adenosylmethionine decarboxylase provide insights into substrate specificity.

Bale S, Baba K, McCloskey DE, Pegg AE, Ealick SE. Bale S, et al. Among authors: ealick se. Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):181-9. doi: 10.1107/S090744490904877X. Epub 2010 Jan 22. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 20124698 Free PMC article.

6

Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.

Zhang Y, Kang SA, Mukherjee T, Bale S, Crane BR, Begley TP, Ealick SE. Zhang Y, et al. Among authors: ealick se. Biochemistry. 2007 Jan 9;46(1):145-55. doi: 10.1021/bi0620095. Biochemistry. 2007. PMID: 17198384

7

Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor.

Soriano EV, Rajashankar KR, Hanes JW, Bale S, Begley TP, Ealick SE. Soriano EV, et al. Among authors: ealick se. Biochemistry. 2008 Feb 5;47(5):1346-57. doi: 10.1021/bi7018282. Epub 2008 Jan 5. Biochemistry. 2008. PMID: 18177053 Free PMC article.

8

HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues.

Bale S, Rajashankar KR, Perry K, Begley TP, Ealick SE. Bale S, et al. Among authors: ealick se. Biochemistry. 2010 Oct 19;49(41):8929-36. doi: 10.1021/bi101209t. Biochemistry. 2010. PMID: 20873853 Free PMC article.

9

Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.

Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP. Chatterjee A, et al. Among authors: ealick se. Nature. 2011 Oct 26;478(7370):542-6. doi: 10.1038/nature10503. Nature. 2011. PMID: 22031445 Free PMC article.

10

The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.

Tolbert WD, Ekstrom JL, Mathews II, Secrist JA 3rd, Kapoor P, Pegg AE, Ealick SE. Tolbert WD, et al. Among authors: ealick se. Biochemistry. 2001 Aug 14;40(32):9484-94. doi: 10.1021/bi010735w. Biochemistry. 2001. PMID: 11583147

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