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Drugs Modulating Renin-Angiotensin System in COVID-19 Treatment.
Labandeira-Garcia JL, Labandeira CM, Valenzuela R, Pedrosa MA, Quijano A, Rodriguez-Perez AI. Labandeira-Garcia JL, et al. Biomedicines. 2022 Feb 21;10(2):502. doi: 10.3390/biomedicines10020502. Biomedicines. 2022. PMID: 35203711 Free PMC article. Review.
A massive worldwide vaccination campaign constitutes the main tool against the COVID-19 pandemic. However, drug treatments are also necessary. Antivirals are the most frequently considered treatments. ...
A massive worldwide vaccination campaign constitutes the main tool against the COVID-19 pandemic. However, drug treatments are also n …
NADPH-Oxidase, Rho-Kinase and Autophagy Mediate the (Pro)renin-Induced Pro-Inflammatory Microglial Response and Enhancement of Dopaminergic Neuron Death.
Lopez-Lopez A, Villar-Cheda B, Quijano A, Garrido-Gil P, Garcia-Garrote M, Díaz-Ruiz C, Muñoz A, Labandeira-Garcia JL. Lopez-Lopez A, et al. Antioxidants (Basel). 2021 Aug 25;10(9):1340. doi: 10.3390/antiox10091340. Antioxidants (Basel). 2021. PMID: 34572972 Free PMC article.
Conditioned medium from (pro)renin-treated microglia increased dopaminergic cell death relative to medium from non-treated microglia. However, these effects were blocked by pre-treatment of microglia with the Rho-kinase inhibitor fasudil. Activation of microglial PRR enhan …
Conditioned medium from (pro)renin-treated microglia increased dopaminergic cell death relative to medium from non-treated microglia. Howeve …
Rho kinase inhibitor fasudil reduces l-DOPA-induced dyskinesia in a rat model of Parkinson's disease.
Lopez-Lopez A, Labandeira CM, Labandeira-Garcia JL, Muñoz A. Lopez-Lopez A, et al. Br J Pharmacol. 2020 Dec;177(24):5622-5641. doi: 10.1111/bph.15275. Epub 2020 Nov 3. Br J Pharmacol. 2020. PMID: 32986850 Free PMC article.
The effects of the ROCK inhibitor fasudil on LID were particularly investigated. ...Furthermore, previous studies have revealed neuroprotective effects of ROCK inhibitors....
The effects of the ROCK inhibitor fasudil on LID were particularly investigated. ...Furthermore, previous studies have revealed neuro …