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Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients.
Davar D, Dzutsev AK, McCulloch JA, Rodrigues RR, Chauvin JM, Morrison RM, Deblasio RN, Menna C, Ding Q, Pagliano O, Zidi B, Zhang S, Badger JH, Vetizou M, Cole AM, Fernandes MR, Prescott S, Costa RGF, Balaji AK, Morgun A, Vujkovic-Cvijin I, Wang H, Borhani AA, Schwartz MB, Dubner HM, Ernst SJ, Rose A, Najjar YG, Belkaid Y, Kirkwood JM, Trinchieri G, Zarour HM. Davar D, et al. Among authors: dzutsev ak. Science. 2021 Feb 5;371(6529):595-602. doi: 10.1126/science.abf3363. Science. 2021. PMID: 33542131 Free PMC article. Clinical Trial.
The Antimicrobial Peptide CRAMP Is Essential for Colon Homeostasis by Maintaining Microbiota Balance.
Yoshimura T, McLean MH, Dzutsev AK, Yao X, Chen K, Huang J, Gong W, Zhou J, Xiang Y, H Badger J, O'hUigin C, Thovarai V, Tessarollo L, Durum SK, Trinchieri G, Bian XW, Wang JM. Yoshimura T, et al. Among authors: dzutsev ak. J Immunol. 2018 Mar 15;200(6):2174-2185. doi: 10.4049/jimmunol.1602073. Epub 2018 Feb 12. J Immunol. 2018. PMID: 29440355 Free PMC article.
Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1.
McCulloch JA, Davar D, Rodrigues RR, Badger JH, Fang JR, Cole AM, Balaji AK, Vetizou M, Prescott SM, Fernandes MR, Costa RGF, Yuan W, Salcedo R, Bahadiroglu E, Roy S, DeBlasio RN, Morrison RM, Chauvin JM, Ding Q, Zidi B, Lowin A, Chakka S, Gao W, Pagliano O, Ernst SJ, Rose A, Newman NK, Morgun A, Zarour HM, Trinchieri G, Dzutsev AK. McCulloch JA, et al. Among authors: dzutsev ak. Nat Med. 2022 Mar;28(3):545-556. doi: 10.1038/s41591-022-01698-2. Epub 2022 Feb 28. Nat Med. 2022. PMID: 35228752 Free PMC article.
Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages.
Li Z, Gurung M, Rodrigues RR, Padiadpu J, Newman NK, Manes NP, Pederson JW, Greer RL, Vasquez-Perez S, You H, Hioki KA, Moulton Z, Fel A, De Nardo D, Dzutsev AK, Nita-Lazar A, Trinchieri G, Shulzhenko N, Morgun A. Li Z, et al. Among authors: dzutsev ak. J Exp Med. 2022 Jul 4;219(7):e20220017. doi: 10.1084/jem.20220017. Epub 2022 Jun 3. J Exp Med. 2022. PMID: 35657352 Free PMC article.
Predicting cancer immunotherapy response from gut microbiomes using machine learning models.
Liang H, Jo JH, Zhang Z, MacGibeny MA, Han J, Proctor DM, Taylor ME, Che Y, Juneau P, Apolo AB, McCulloch JA, Davar D, Zarour HM, Dzutsev AK, Brownell I, Trinchieri G, Gulley JL, Kong HH. Liang H, et al. Among authors: dzutsev ak. Oncotarget. 2022 Jul 19;13:876-889. doi: 10.18632/oncotarget.28252. eCollection 2022. Oncotarget. 2022. PMID: 35875611 Free PMC article.
Transkingdom Network Analysis (TkNA): a systems framework for inferring causal factors underlying host-microbiota and other multi-omic interactions.
Newman NK, Macovsky M, Rodrigues RR, Bruce AM, Pederson JW, Patil SS, Padiadpu J, Dzutsev AK, Shulzhenko N, Trinchieri G, Brown K, Morgun A. Newman NK, et al. Among authors: dzutsev ak. bioRxiv [Preprint]. 2023 Mar 29:2023.02.22.529449. doi: 10.1101/2023.02.22.529449. bioRxiv. 2023. PMID: 36865280 Free PMC article. Updated. Preprint.
20 results