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Small Molecule Targeting of Specific BAF (mSWI/SNF) Complexes for HIV Latency Reversal.
Marian CA, Stoszko M, Wang L, Leighty MW, de Crignis E, Maschinot CA, Gatchalian J, Carter BC, Chowdhury B, Hargreaves DC, Duvall JR, Crabtree GR, Mahmoudi T, Dykhuizen EC. Marian CA, et al. Among authors: dykhuizen ec. Cell Chem Biol. 2018 Dec 20;25(12):1443-1455.e14. doi: 10.1016/j.chembiol.2018.08.004. Epub 2018 Sep 6. Cell Chem Biol. 2018. PMID: 30197195 Free PMC article.
Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.
Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Wang S, et al. Among authors: dykhuizen ec. ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12. ACS Chem Biol. 2020. PMID: 31755685 Free PMC article.
Polycomb Paralog Chromodomain Inhibitors Active against Both CBX6 and CBX8*.
Milosevich N, Wilson CR, Brown TM, Alpsoy A, Wang S, Connelly KE, Sinclair KAD, Ponio FR, Hof R, Dykhuizen EC, Hof F. Milosevich N, et al. Among authors: dykhuizen ec. ChemMedChem. 2021 Oct 6;16(19):3027-3034. doi: 10.1002/cmdc.202100262. Epub 2021 Jul 23. ChemMedChem. 2021. PMID: 34174168 Free PMC article.
Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.
Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Shishodia S, et al. Among authors: dykhuizen ec. J Med Chem. 2022 Oct 27;65(20):13714-13735. doi: 10.1021/acs.jmedchem.2c00864. Epub 2022 Oct 13. J Med Chem. 2022. PMID: 36227159 Free PMC article.
PBRM1 bromodomains associate with RNA to facilitate chromatin association.
De Silva SM, Dhiman A, Sood S, Mercedes KF, Simmons WJ, Henen MA, Vögeli B, Dykhuizen EC, Musselman CA. De Silva SM, et al. Among authors: dykhuizen ec. Nucleic Acids Res. 2023 May 8;51(8):3631-3649. doi: 10.1093/nar/gkad072. Nucleic Acids Res. 2023. PMID: 36808431 Free PMC article.
39 results