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Pseudotime dynamics of T cells in pancreatic ductal adenocarcinoma inform distinct functional states within the regulatory and cytotoxic T cells.
Jainarayanan A, Mouroug-Anand N, Arbe-Barnes EH, Bush AJ, Bashford-Rogers R, Frampton A, Heij L, Middleton M, Dustin ML, Abu-Shah E, Sivakumar S. Jainarayanan A, et al. Among authors: dustin ml. iScience. 2023 Mar 7;26(4):106324. doi: 10.1016/j.isci.2023.106324. eCollection 2023 Apr 21. iScience. 2023. PMID: 36968070 Free PMC article.
Curving out a new path: CD28/B7 cis interactions.
Zhou XMM, Mørch AM, Dustin ML. Zhou XMM, et al. Among authors: dustin ml. Immunity. 2023 Jun 13;56(6):1155-1157. doi: 10.1016/j.immuni.2023.05.002. Immunity. 2023. PMID: 37315528
LAT1 enables T cell activation under inflammatory conditions.
Ogbechi J, Wright HL, Balint S, Topping LM, Kristina Z, Huang YS, Pantazi E, Swart M, Windell D, Marin E, Wempe MF, Endou H, Thomas AM, Filer A, Stone TW, Clarke AJ, Dustin ML, Williams RO. Ogbechi J, et al. Among authors: dustin ml. J Autoimmun. 2023 Jul;138:103031. doi: 10.1016/j.jaut.2023.103031. Epub 2023 May 23. J Autoimmun. 2023. PMID: 37229811
Publisher Correction: Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou AV, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V. Barnkob MB, et al. Among authors: dustin ml. Nat Commun. 2024 Apr 24;15(1):3448. doi: 10.1038/s41467-024-47775-7. Nat Commun. 2024. PMID: 38658563 Free PMC article. No abstract available.
Semmaphorin 3 A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells.
Barnkob MB, Michaels YS, André V, Macklin PS, Gileadi U, Valvo S, Rei M, Kulicke C, Chen JL, Jain V, Woodcock VK, Colin-York H, Hadjinicolaou AV, Kong Y, Mayya V, Mazet JM, Mead GJ, Bull JA, Rijal P, Pugh CW, Townsend AR, Gérard A, Olsen LR, Fritzsche M, Fulga TA, Dustin ML, Jones EY, Cerundolo V. Barnkob MB, et al. Among authors: dustin ml. Nat Commun. 2024 Apr 12;15(1):3173. doi: 10.1038/s41467-024-47424-z. Nat Commun. 2024. PMID: 38609390 Free PMC article.
Unconventional human CD61 pairing with CD103 promotes TCR signaling and antigen-specific T cell cytotoxicity.
Hamid MHBA, Cespedes PF, Jin C, Chen JL, Gileadi U, Antoun E, Liang Z, Gao F, Teague R, Manoharan N, Maldonado-Perez D, Khalid-Alham N, Cerundolo L, Ciaoca R, Hester SS, Pinto-Fernández A, Draganov SD, Vendrell I, Liu G, Yao X, Kvalvaag A, Dominey-Foy DCC, Nanayakkara C, Kanellakis N, Chen YL, Waugh C, Clark SA, Clark K, Sopp P, Rahman NM, Verrill C, Kessler BM, Ogg G, Fernandes RA, Fisher R, Peng Y, Dustin ML, Dong T. Hamid MHBA, et al. Among authors: dustin ml. Nat Immunol. 2024 May;25(5):834-846. doi: 10.1038/s41590-024-01802-3. Epub 2024 Apr 1. Nat Immunol. 2024. PMID: 38561495 Free PMC article.
Transmembrane domain-driven PD-1 dimers mediate T cell inhibition.
Philips EA, Liu J, Kvalvaag A, Mørch AM, Tocheva AS, Ng C, Liang H, Ahearn IM, Pan R, Luo CC, Leithner A, Qin Z, Zhou Y, Garcia-España A, Mor A, Littman DR, Dustin ML, Wang J, Kong XP. Philips EA, et al. Among authors: dustin ml. Sci Immunol. 2024 Mar 8;9(93):eade6256. doi: 10.1126/sciimmunol.ade6256. Epub 2024 Mar 8. Sci Immunol. 2024. PMID: 38457513
Using CombiCells, a platform for titration and combinatorial display of cell surface ligands, to study T-cell antigen sensitivity modulation by accessory receptors.
Patel A, Andre V, Eguiguren SB, Barton MI, Burton J, Denham EM, Pettmann J, Mørch AM, Kutuzov MA, Siller-Farfán JA, Dustin ML, van der Merwe PA, Dushek O. Patel A, et al. Among authors: dustin ml. EMBO J. 2024 Jan;43(1):132-150. doi: 10.1038/s44318-023-00012-1. Epub 2023 Dec 18. EMBO J. 2024. PMID: 38177315 Free PMC article.
A partial human LCK defect causes a T cell immunodeficiency with intestinal inflammation.
Lui VG, Hoenig M, Cabrera-Martinez B, Baxter RM, Garcia-Perez JE, Bailey O, Acharya A, Lundquist K, Capera J, Matusewicz P, Hartl FA, D'Abramo M, Alba J, Jacobsen EM, Niewolik D, Lorenz M, Pannicke U, Schulz AS, Debatin KM, Schamel WW, Minguet S, Gumbart JC, Dustin ML, Cambier JC, Schwarz K, Hsieh EWY. Lui VG, et al. Among authors: dustin ml. J Exp Med. 2024 Jan 1;221(1):e20230927. doi: 10.1084/jem.20230927. Epub 2023 Nov 14. J Exp Med. 2024. PMID: 37962568 Free PMC article.
386 results